川木香根中1个新的三萜和1个新的甾体类化合物的研究

A new triterpenoid and a new steroid from roots of Vladimiria souliei

目的对川木香属植物川木香Vladimiriasouliei根的化学成分进行研究。方法采用正相硅胶柱色谱、SephadexLH-20柱色谱、MCI中压柱色谱、反相C18柱色谱、高效液相色谱等一系列方法对其进行分离纯化,根据其理化性质和波谱数据等对化合物结构进行鉴定,并通过单晶X-射线衍射实验,确定化合物1的绝对构型。结果从川木香根中共分离鉴定了3个化合物,分别命名为25-羟基熊果醇(1)、川木香甾醇(2)和豆甾醇(3)。结论化合物1和2为新化合物,化合物3为首次从川木香根中分离得到。

Objective To study the chemical compositions from the roots of Vladimiria souliei.Methods The ethanol extract of the roots of V.souliei was isolated by silica gel,Sephadex LH-20,MCI,HPLC,and C18 reverse-phase column chromatographies.Their physical and chemical structures were elucidated by analysis of NMR and MS spectroscopic data,and the absolute configuration of compound 1 was confirmed by Cu-KαX-ray crystallographic analysis.Results Three compounds were isolated from the roots of V.souliei,and named as 25-hydroxy-uvaol(1),vlasoudiol(2),and stigmasterol(3),respectively.Conclusion Compounds 1 and 2 are identified as new compounds,and compound 3 is isolated from the roots of V.souliei for the first time.