雷公藤甲素抗肿瘤新型给药系统研究进展

Research progress on new drug delivery system of triptolide for anticancer therapy

雷公藤甲素具有广谱、高效的抗肿瘤活性,但其具有水溶性差、体内消除快和毒副作用强等缺点,限制了雷公藤甲素的临床应用。新型给药系统是靶向递送雷公藤甲素的理想载体,能够将其有效运送至肿瘤组织,提高对肿瘤的治疗效果,新型给药系统在改善雷公藤甲素溶解度、降低其毒副作用、提高生物利用度等方面有良好的应用前景。综述近10年来基于脂质体、聚合物胶束、纳米粒的雷公藤甲素抗肿瘤新型给药系统的研究进展,以期为雷公藤甲素新型给药系统在抗肿瘤药物的开发和应用等方面提供参考。

Triptolide had broad-spectrum and high-efficient anti-cancer activity,however,its clinical application was limited by the poor water solubility,in vivo rapid elimination,and strong toxicities and side effects.New drug delivery system was the ideal vehicle for targeted delivery of triptolide,which can effectively deliver triptolide to the cancer tissue,and increase the efficiency of tumor therapy.New drug delivery system had great application prospect in improving solubility of triptolide,reducing side effect,and increasing bioavailability.This article reviewed the research progress of new drug delivery system of triptolide based on liposome,polymer micelle and nanoparticle in the past decade,providing some references for the development and application of new drug delivery system of triptolide.