巴西甘菊花化学成分研究(Ⅰ)

Chemical constituents from Achyrocline satureioides(Ⅰ)

目的研究巴西甘菊花Achyrocline satureioides的化学成分。方法应用多种色谱技术对巴西甘菊花进行分离纯化,并通过光谱方法鉴定化合物的结构。结果从巴西甘菊花醋酸乙酯部位中分离得到21个化合物,分别鉴定为香树脂醇(1)、豆甾-4,6,8,22-四烯-3-酮(2)、豆甾-4-烯-3,6-二酮(3)、clovandiol(4)、caryolane-1,9β-diol(5)、lepidissipyrone(6)、5,7-二羟基-3,6-二甲氧基黄酮(7)、槲皮素-7-O-β-D-葡萄糖苷(8)、5,7-二羟基二氢黄酮(9)、二氢槲皮素(10)、槲皮素-4′-O-β-D-葡萄吡喃糖苷(11)、helichrysetin(12)、3-[5,7-dihydroxy-2,2-dimethyl-8-(2-(S)-methyl-butanoyl)-2H-chromen-6-yl-methyl]-6-ethyl-4-hydroxy-5-methyl-pyran-2-one(13)、槲皮素(14)、原儿茶酸(15)、(+)-(3R)-3-hydroxyl-4,4-dimethyl-4-butyrolactone(16)、(4S,5R)-5-(4′-methyl-3′-pentenyl)-4-hydroxy-5-methyldihydrofuran-2-one(17)、芫花素(18)、槲皮素-3-甲醚(19)、高良姜素(20)、新野樱苷(21)。结论化合物1、4、5、16、17、21为首次从该属植物中分离得到,化合物1~12、16~18、21为首次从该植物中分离得到。

Objective To study the chemical constituents from Achyrocline satureioides.Methods Chemical constituents from A.satureioides were separated and purified by a variety of chromatographic techniques,and their structures were identified by various spectroscopic methods.Results Twenty-one compounds were isolated from ethyl acetate fraction of the plant,which wereα-amyrin(1),ergosta-4,6,8,22-tetraene-3-one(2),(R)-24-ethylcholest-4-en-3,6-dione(3),clovandiol(4),caryolane-1,9β-diol(5),lepidissipyrone(6),5,7-dihydroxy-3,6-dimethoxyflavone(7),quercetin-7-O-β-D-glucoside(8),pinocembrin(9),(2 R,3 R)-taxifolin(10),quercetin-4′-O-β-D-glucoside(11),helichrysetin(12),3-[5,7-dihydroxy-2,2-dimethyl-8-(2-(S)-methyl-butanoyl)-2 H-chromen-6-yl-methyl]-6-ethyl-4-hydroxy-5-methyl-pyran-2-one(13),quercetin(14),protocatechuic acid(15),(+)-(3 R)-3-hydroxyl-4,4-dimethyl-4-butyrolactone(16),(4 S,5 R)-5-(4′-methyl-3′-pentenyl)-4-hydroxy-5-methyldihydrofuran-2-one(17),genkwanin(18),quercetin-3-methyl ether(19),galangin(20),and neosakuranin(21).Conclusion Compounds 1,4,5,16,17,and 21 are obtained from the genus for the first time,and compounds 1—12,16—18,and 21 are obtained from the plant for the first time.