鲁桑枝中黄酮类成分研究

Flavonoids from twigs of Morus multicaulis

目的研究鲁桑Morus multicaulis枝中的化学成分。方法采用多种色谱技术进行分离纯化,通过理化性质和波谱学数据对其进行结构鉴定。结果从鲁桑枝90%乙醇提取物中得到6个黄酮类成分,分别鉴定为桑枝酮A(1)、carpachromene(2)、补骨脂乙素(3)、异甘草素(4)、芹菜素(5)和槲皮素(6),其中化合物1的绝对构型通过圆二色谱量子化学计算得到了确定。结论化合物1为新化合物,命名为桑枝酮A,化合物2～4为首次从该植物中分离得到。

Objective To investigate the chemical compounds from the twigs of Morus multicaulis.Methods The chemical constituents were isolated by various chromatographic methods from 90%ethanol aqueous extract of M.multicaulis and the structures were elucidated by a combined analysis of physicochemical properties,as well as spectroscopic methods including UV,IR,MS ECD and NMR.Results Six flavonoids were isolated and the structures were identified as moritwigsone A(1),carpachromene(2),isobavachalcone(3),isoliquiritigenin(4),apigenin(5),and quercitrin(6).The absolute configuration of compound 1 was determined by electronic circular dichroism(ECD)calculation.Conclusion Compound 1 is a new compound,named moritwigsone A,and compounds 2—4 are isolated from this plant for the first time.