丹参川芎嗪注射液联合甲钴胺对糖尿病周围神经病变患者的治疗效果和对氧化应激反应的影响

Effects of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection on diabetic peripheral neuropathy and oxidative stress response

目的研究丹参川芎嗪注射液穴位注射联合甲钴胺对糖尿病周围神经病变(DPN)患者的疗效,以及对患者氧化应激反应的影响。方法选取本院神经内科门诊及住院部在2016年3月—2018年2月期间收治的DPN患者100例,根据随机数字表法将患者分为观察组和对照组,每组50例。两组均给予常规降糖药物治疗以及控制饮食、运动等,对照组给予甲钴胺片治疗,观察组给予甲钴胺片的基础上,联合丹参川芎嗪注射液穴位注射,治疗4周为1个疗程,连续2个疗程。观察比较两组治疗前后临床症状评分,血清超氧化物歧化酶(SOD)、γ-谷氨酰转肽酶(GGT)、铁蛋白(SF)、总抗氧化能力(T-AOC)和丙二醛(MDA)等氧化应激反应指标的水平,正中神经和腓总神经运动传导速度(MNCV)、正中神经和腓总神经感觉传导速度(SNCV),以及评价疗效。结果治疗后,两组各项指标较治疗前均有所改善(P<0.05),观察组临床症状评分明显低于对照组;观察组SOD水平升高,高于对照组(P<0.05);GGT、SF、T-AOC、MDA水平降低,且低于对照组(P<0.05);观察组MNCV和SNCV均升高,且高于对照组(P<0.05);观察组总有效率为84.00%,显著高于对照组的64.00%(P<0.05)。结论采用丹参川芎嗪注射液穴位注射联合甲钴胺治疗DPN患者,可显著减轻患者体内氧化应激反应,促进神经功能恢复,改善患者临床症状,安全性高,值得临床推广。

Objective To study the therapeutic effect of point injection of Salvia Miltiorrhiza and Ligustrazine Hydrochloride Injection(SMLHI)on diabetic peripheral neuropathy(DPN)patients and its effect on oxidative stress response.Methods A total of 100 DPN patients were selected from the Neurology Department of the Fifth Affiliated Hospital of Zhengzhou University from March 2016 to February 2018.According to the random number table method,the patients were divided into observation group and control group with50 cases in each group.Each group was treated with routine hypoglycemic drugs,diet control and exercise control,while the control group was treated with Mecobalamin Tablets.The observation group was treated with Mecobalamin Tablets combined with SMLHI at acupoints for 4 weeks as a course of treatment for two consecutive courses of treatment.The clinical symptom score,serum superoxide dismutase(SOD),gamma-glutamyltransferase(GGT),ferritin(SF),total anti-oxidant capacity(T-AOC),and malondialdehyde(MDA)levels,median nerve and peroneal nerve conduction velocity(MNCV),median nerve,peroneal nerve conduction velocity(SNCV),and curative effect were observed and compared before and after treatment.Results After treatment,the clinical symptom score of the observation group was significantly lower,and the total effective rate of the observation group was 84.00%,which was higher than that of the control group 64.00%(P<0.05).The SOD level in the observation group was higher,while the GGT,SF,T-AOC,and MDA levels were lower(P<0.05).The MNCV and SNCV in the observation group were higher(P<0.05).Conclusion Acupoint injection of SMLHI for DPN patients can significantly reduce oxidative stress reaction in vivo,promote the recovery of nerve function,improve clinical symptoms of patients with high safety,which is worthy of clinical promotion.