真菌转化中药活性成分研究进展

Research progress on active components of fungi transforming Chinese materia medica

中药活性成分是其发挥药效的物质基础,是实现中药现代化的关键。如何提高中药活性成分含量,已成为研究的热点,微生物转化是其关键技术之一。实践证明,菌株不同,中药种类不同,转化效果不同。因此,就真菌转化萜类、生物碱类、苯丙素类、醌类、甾体类、有机酸类等中药活性成分研究进展进行综述。

Active components of Chinese materia medica(CMM)are the material basis of its efficacy and the keys to realize modernization of CMM.How to improve the content of active ingredients of CMM has become a research hotspot,and microbial transformation is one of its key technologies.The practice has proved that the strains are different,the types of CMM are different,and the transformation effects are different.Therefore,the research on fungal transformation of CMM active ingredients such as terpenes,alkaloids,phenylpropanoids,quinones,steroids,organic acids,etc.is reviewed in this study.