基于网络药理学的疏风解毒胶囊配伍合理性研究

Study on compatibility rationality of Shufeng Jiedu Capsule based on network pharmacology

目的探究疏风解毒胶囊治疗上呼吸道感染的配伍合理性。方法实验采用网络药理学的方法,对疏风解毒胶囊中清热解毒组、解表组和甘草组的32个化合物的作用靶点和通路进行预测和筛选,通过数据整合分析,剖析该方的作用特点及配伍规律。结果 32个化合物可作用于94个相关靶点和34条相关通路,主要涉及炎症反应、细菌脂多糖反应、免疫反应等相关过程。3组既有共同的作用靶点群及通路群,又各有偏重,协同发挥治疗作用。结论清热解毒组通过干预炎症反应、细菌脂多糖反应、防御反应和免疫反应等相关过程发挥治疗作用;解表组除可与清热解毒组协同发挥药效外,亦可通过多途径作用于发汗解热过程;甘草组从抗炎、增强机体免疫等方面起到辅助治疗作用,体现了疏风解毒胶囊的配伍合理性。

Objective To explore the compatibility rationality of Shufeng Jiedu Capsule(SJC)for the treatment of upper respiratory infection(URI).Methods The potential targets and pathways of 32 compounds selected from‘heat-clearing and detoxicating group’(HCDG),‘relieving exterior syndrome group’(RESG),and‘Glycyrrhiza uralensis group(GUG)’of SJC were predicted by the methods of network pharmacology.The mechanism and compatibility rationality of SJC were analyzed by data integration and analysis.Results The in silico prediction results showed that 32 compounds of SJC affected 34 related pathways through 94 target proteins which mainly involved with inflammation,lipopolysaccharide and bacterium response,immunoreaction and so on.The three groups of HCDG,RESG,and GUG not only showed common targets and pathways but also had their own emphasis to exert synergistic effects.Conclusion HCDG plays a therapeutic role by intervening in related physiological process,such as inflammatory response,lipopolysaccharide and bacterium response,defense response and immune response.In addition to providing synergistic effects with HCDG,RESG can also intervene in the process of the sweating and antipyretic through multiple pathways.GUG showed auxiliary therapeutic effect by participating in processes of anti-inflammatory and enhancing the body immunity.