LncRNA SNHG12、SNHG15及SNHG16在肺腺癌的表达及意义

Expression of LncRNA SNHG12, SNHG15 and SNHG16 in lung adenocarcinoma and their clinical significance

目的研究LncRNA SNHG12,SNHG15及SNHG16在肺腺癌的表达及其与肺腺癌患者临床病理特征的相关性。方法采用实时荧光定量PCR(qRT-PCR)检测肺腺癌及相应癌旁组织中LncRNA(长链非编码RNA)SNHG12,SNHG15及SNHG16的表达情况。结果 LncRNA SNHG12,SNHG15及SNHG16在肺腺癌组织中的表达量均高于癌旁组织。但是这种表达差异与肺腺癌患者的性别、年龄、淋巴结转移及五年生存率等临床病理特征无相关性。仅SNHG15和SNHG16的表达与TNM分期有关。其表达越高,TNM分期越低。结论 SNHG15和SNHG16可能参与了肺腺癌的发生发展,并导致了患者的不良预后。

Objective To detect the expression of lncRNA SNHG12,SNHG15 and SNHG16 in lung adenocarcinoma tissue and to analyse the correlations between those 3 factors above and clinicopathological implications.Methods LncRNA SNHG12,SNHG15 and SNHG16 expression in lung adenocarcinoma and adjacent tissues was detected by qRT-PCR.Then the correlation was analysed between the expression of SNHG12,SNHG15 or SNHG16 and clinicopathological characteristics of lung adenocarcinoma.Results The expression of LncRNA SNHG12,SNHG15 and SNHG16 in lung adenocarcinoma tissues was higher than that of adjacent tissues.There was a negative relationship between the expression of SNHG15 or SNHG16 in lung adenocarcinoma and TNM stages.Conclusion SNHG15 and SNHG16 may be involved in the occurrence and development of lung adenocarcinoma and lead to poor prognosis of patients.