丹参川芎嗪注射液治疗重度急性胰腺炎的疗效观察

The curative effect of salviae miltiorrhizae and ligustrazine injection in treating severe acute pancreatitis

目的探讨丹参川芎嗪注射液治疗重度急性胰腺炎的临床疗效。方法对照组22例给予常规治疗:禁食,胃肠减压,减少胰液分泌,抑制胰酶活性,抑制炎症反应,抑制胃酸分泌,维持水电解质酸碱平衡等治疗;治疗组20例在常规治疗基础上加用丹参川芎嗪注射液静脉滴注。结果治疗组患者的血淀粉酶和尿淀粉酶恢复正常时间、腹痛缓解时间均快于对照组,住院时间明显缩短(P<0.05),且MODS发生率也明显降低(P<0.05)。结论丹参川芎嗪注射液对降低SAP的MODS发生率、缩短病程具有较好的临床疗效。

Objective To investigate curative effect of salviae miltiorrhizae and ligustrazine injection in treating severe acute pancreatitis. Methods The 22 cases in control group received conventional therapy, absolute diet, gastrointestinal decompression, reduce pancreatic secretion, inhibit inflammatory response, inhibit trypsin activity, inhibition of gastric acid secretion, maintain water electrolyte and acid-base balance treatment; 20 cases in treatment group were given salviae miltiorrhizae and ligustrazine injection through intravenous drip on the basis of conventional treatment. Results The time of blood and urine amylase returned to normal level and abdominal pain relief time of patients in treatment group were significantly faster than that of the control group, the duration of hospital stays in treatment group were sig-nificantly shortened(P<0.05), the incidence rate of MODS was also significantly decreased(P<0.05). Conclusion Salviae miltiorrhizae and ligustrazine injection has good clinical efficacy on decreased the incidence rate of MODS and shorten-ing the course of severe acute pancreatitis.