角膜缘干细胞移植治疗翼状胬肉对2型糖尿病患者泪膜功能的影响

The impact of limbal stem cell transplantation in the treatment of pterygium on the tear film function in patients with type 2 diabetes mellitus

目的探讨角膜缘干细胞移植治疗翼状胬肉对2型糖尿病患者泪膜功能的影响。方法选取昌平区医院2012年1月~2014年12月患有原发性翼状胬肉的2型糖尿病患者70例,测量双眼的基础泪液分泌、泪河面积及泪膜破裂时间。术眼行翼状胬肉切除联合角膜缘干细胞移植术,分别测量患者术前、术后2周及术后2个月的基础泪液分泌、泪河面积及泪膜破裂时间,分析角膜缘干细胞移植治疗翼状胬肉对2型糖尿病患者泪膜功能的影响。结果术前两眼泪液分泌试验及泪河面积比较差异无统计学意义(P>0.05),术前两眼泪膜破裂时间的差异有统计学意义(P<0.05)。术眼术前、术后泪液分泌试验及泪河面积比较差异无统计学意义(P>0.05),术前、术后泪膜破裂时间的差异有统计学意义(P<0.05)。结论角膜缘干细胞移植治疗翼状胬肉术后泪膜稳定性优于术前,可使2型糖尿病患者泪膜功能得到改善。

Objective To investigate the impact of limbal stem cell transplantation in the treatment of pterygium on the tear film function in patients with type 2 diabetes mellitus. Methods All 70 cases of primary pterygium patients with type 2 diabetes mellitus in Beijing Changping district Hospital from January 2012 to December 2014 were chosen.Basal tear secretion, tears river area and tear film break-up time of their two eyes were measured. Excision of pterygium combined with limbal stem cell transplantation was conducted. Basal tear secretion, tears river area and tear film break-up time before surgery, two weeks and two months after surgery were measured respectively, and the impact of limbal stem cell transplantation in the treatment of pterygium on the tear film function in patients with type 2 diabetes mellitus was analyzed. Results The differences of preoperative Schirmer test and tear river area of two eyes were not statistically significant(P>0.05), and the difference of preoperative tear film break-up time of two eyes was statistically significant(P<0.05). The differences of the operative eyes Schirmer test and tears river area before and after surgery were not statistically significant(P>0.05), and the difference of preoperative and postoperative tear break-up time was statistically significant(P<0.05). Conclusion The tear film after the limbal stem cell transplantation in the treatment of pterygium is more stable than that before surgery, and the limbal stem cell transplantation can improve tear film function in patients with type 2 diabetes mellitus.