重复经颅磁刺激对帕金森病运动与非运动症状的影响

Effect of repetitive transcranial magnetic stimulation on movement and non-motor symptoms for Parkinson's disease

目的探讨重复经颅磁刺激对帕金森病患者运动及非运动症状的影响。方法选择帕金森病患者43例为研究对象,其中22例患者予常规药物治疗(对照组),21例患者在药物治疗基础上予重复经颅磁刺激治疗(研究组)。比较两组患者治疗前后运动及非运动指标变化情况。结果研究组患者治疗1个疗程后、治疗后1个月、治疗后3个月UPDRSⅠ、UPDRSⅡ、UPDRSⅢ及总分均显著下降(P<0.05)。结论在抗帕金森药物治疗的基础上加用重复经颅磁刺激治疗帕金森病,能够显著改善患者的运动及非运动功能。

Objective To discuss effect of repetitive transcranial magnetic stimulation on movement and non-motor symptoms for Parkinson’s disease. Methods A total of 43 cases with Parkinson’s disease were selected, among whom,22 cases of control group were treated by conventional drug therapy, and 21 cases of study group were treated by r-TMS based on conventional drug therapy. Movement and non-motor symptoms before and after treatment of two groups were compared. Results UPDRS Ⅰ, UPDRS Ⅱ, UPDRS Ⅲ and total scores of study group after a course of treatment,one month, three months were lower apparently than control group(P<0.05). Conclusion Movement and non-motor symptoms can improve apparently with r TMS based on conventional drug therapy for Parkinson’s disease.