18例先天性内耳发育不良继发脑脊液耳漏诊疗总结（英文）

Cerebrospinal fluid otorrhea secondary to congenital inner ear dysplasia: diagnosis and management of 18 cases

目的:介绍先天性内耳发育不良继发耳源性脑脊液渗漏的临床表现、诊断、手术方法及预后。创新点:总结了先天性内耳发育不良所致的脑脊液耳漏儿童与成人的畸形特点,为先天性内耳畸形导致的脑脊液耳漏提供诊疗参考。方法:回顾性分析2007～2017年我组18例内耳发育不良继发耳源性脑脊液渗漏患者,随访至少4个月,平均随访时间为3年。介绍所有患者的临床表现特点,包括自述症状、影像学表现、手术方法及修复方法、术中渗漏位置、术后病程、手术成功率等。结论:在先天性内耳发育不良所致的脑脊液耳漏中,儿童的内耳畸形情况较成人更为严重。最常见的症状是脑膜炎、听力障碍和脑脊液耳漏或鼻漏。高分辨率CT(HRCT)对本病具有较高的诊断准确率。最常见的瘘口位于椭圆窗周围,包括镫骨足板和环形韧带。

Objective:To describe the characteristics of the clinical presentation,diagnosis,surgical methods,and outcomes of patients with otogenic cerebrospinal fluid(CSF)leakage secondary to congenital inner ear dysplasia.Methods:A retrospective review was performed of 18 patients with otogenic CSF leakage secondary to inner ear dysplasia who underwent surgery in our group from 2007 to 2017 and had a follow-up of at least 4 months.The average length of follow-up was three years.The characteristics of the clinical presentations of all patients,such as self-reported symptoms,radiographic findings,surgical approaches and methods of repair,position of the leakage during surgery,and postoperative course,including the success rate of surgery,are presented.Results:The patients presented mostly with typical symptoms of meningitis,severe hearing impairment,and CSF otorrhea or rhinorrhea.All 18 patients had at least one previous episode of meningitis accompanied by a severe hearing impairment.The preoperative audiograms of 17 patients showed profound sensorineural hearing loss,and one patient had conductive hearing loss.Twelve patients presented with an initial onset of otorrhea,and two had accompanying rhinorrhea.Six patients complained of rhinorrhea,two of whom were misdiagnosed with CSF rhinorrhea and underwent transnasal endoscopy at another hospital.High-resolution computed tomography(HRCT)images can reveal developments in the inner ear,such as expansion of a vestibular cyst,unclear structure of the semicircular canal or cochlea,or signs of effusion in the middle ear or mastoid,which strongly suggest the possibility of CSF otorrhea.The children in the study suffered more severe dysplasia than adults.All 18 patients had CSF leakage identified during surgery.The most common defect sites were in the stapes footplates(55.6%),and 38.9%of patients had a leak around the oval window.One patient had a return of CSF otorrhea during the postoperative period,which did not re-occur following a second repair.Conclusions:CSF otorrhea due to congenital inner ear dysplasia is more severe in children than in adults.The most common symptoms were meningitis,hearing impairment,and CSF otorrhea or rhinorrhea.HRCT has high diagnostic accuracy for this disease.The most common fistula site was around the oval window,including the stapes footplates and the annular ligament.