腹腔热灌注化疗在胃癌治疗中的应用研究

Application of intraperitoneal hyperthermic perfusion for stomach cancer

目的 研究腹腔热灌注化疗对胃癌的治疗效果。方法 选行规范根治术的胃癌病人 70例 ,随机分为 :术后腹腔内热灌注化疗组 (A组 ,n =35 )和全身化疗组 (B组 ,n =35 ) ,观察两组病人在治疗过程中肝、肾功能、体温、血细胞计数改变及术后生存率等。结果 B组病人术后所出现的毒副反应人数和程度都较A组多且重 ;术后 1、3、5年A组生存率分别为 88.5 %、6 5 .4 %、5 3.8% ,B组为 73.3%、36 .7%、2 6 .7%。A组术后 3、5年的生存率均明显高于B组 ,差异有显著性意义 (P <0 .0 5 )。结论 腹腔热灌注化疗能明显提高胃癌术后病人的生存率和生存质量。

Objective To study the effect of intraperitoneal hyperthermic perfusion(IPHP) on stomach cancer. Methods Seventy patients with gastric cancer were selected and divided into A group(IPHP was applied to patients after radical operation,n=35) and B group( received systemic chemotherapy, n=35). Hepatic and renal function, body temperature, cytometry and survival rate in all patients were observed. Results The chemotherapeutic adverse reactions in B group were more grievous than in A group. The 1-year、3-year and 5-year survival rates of A group and B group were 88.5%、65.4%、 53.8%and 73.3%、36.7%、26.7%; respectively. The 3-year and 5-year survival rates in A group were both significantly higher than that in B group (P<0.05).Conclusion IPHP with chemotherapeutic agents can improve the survival rate and life quality of postoperative stomach cancer patients.