α-链蛋白在结直肠癌中的表达及其与浸润转移的关系

Relationship between the expression of α-Catenin and the invasion and metastasis of colorectal carcinoma

目的 探讨α 链蛋白 (α catenin)的表达与结直肠癌浸润侵袭特性之间的关系。方法 应用免疫组织化学方法检测α 链蛋白在 5 4例结直肠癌组织中的表达。结果 在正常结肠粘膜 ,α 链蛋白表达主要位于细胞膜上。 5 4例结直肠癌标本中 32例α 链蛋白表达减低 ,减低率为 5 9.2 % (32 /5 4 ) ,α 链蛋白与肿瘤浸润深度和淋巴结及肝脏的转移有明显相关性。结论 α 链蛋白在结直肠癌组织中表达减低是结直肠癌重要的恶性生物学特征。

Objective To investigate the relationship between the expression of α-catenin in human colorectal carcinoma and the invasive characters of colorectal cacer. Methods The expression of α-catenin was examined in 54 cases with colorectal cancer by immuohistochemistry. Results In normal colorectal mucosa, α-catenin was expressed uniformly at the cell membrane.Reduced expression of α-catenin was observed in 32(59.2%) of cases and found to be significantly correlated with the depth of infiltration of the patients' with colorectal cancer and its metastasis to lymph nodes and liver. Conclusion The down-regulation of α-catenin is a significant malignant character of colorectal cancer.