糖缺乏转铁蛋白检测对酒精性肝病的诊断价值

Determination of serum carbohydrate-deficient transferrin in the diagnosis of alcoholic liver disease

目的 评价糖缺乏转铁蛋白 (CDT)对酒精性肝病的诊断价值。方法 选取 36例酒精性肝病、30例嗜酒者、30例非酒精性肝病和 30名健康者用离子交换色谱与免疫比浊法结合定量检测CDT ,同时检测γ 谷氨酰基转移酶 (GGT)等肝功能指标。结果 酒精性肝病组CDT为 (4.32± 1.2 2 ) % ,嗜酒者组为 (2 .87± 1.0 3) % ,非酒精性肝病组为 (2 .74± 0 .86 ) % ,正常对照组为 (2 .4 5± 0 .2 9) %。酒精性肝病组与正常组比较差异有显著性 (P<0 .0 0 1)。

Objective To assess the reliability of carbohydrate deficient transferrin(CDT) in the diagnosis of alcoholic liver disease(ALD). Methods 36 patients with ALD, 30 cases of alcoholism, 30 patients with nonalcoholic liver disease(NALD), and 30 healthy subjects as control were studied. Serum CDT was assayed by ion exchange column chromatography and turbidimetric immunoassay. ALT,AST and GGT were also examined. Results CDT were (4.32±1.22)% in ALD, (2.87±1.03)% in alcoholism, (2.74±0.86)% in NALD and (2.45±0.29)% in healthy control. The CDT of patients with ALD was significantly higher than that of the healthy people. Conclusions CDT may be useful in diagnosing ALD.