2002年广州地区临床分离肠球菌药敏监测结果分析

Surveillance analysis of drug resistance of Enterococcus isolated in clinical laboratories of Guangzhou district in 2002

目的 了解广州地区临床分离的 35 0株肠球菌的耐药性。方法 统一采用纸片扩散法进行试验 ,以美国NCCLS文件为执行标准 ,每次试验的质控数据均有标准要求。结果 有 8家广州市三级甲等医院实验室参加耐药性监测工作 ,统计临床分离肠球菌 35 0株 ,其中粪肠球菌 2 79株 (79.7% ) ,屎肠球菌 39株 (11.1% ) ,鸟肠球菌 10株 (2 .9% ) ,其他肠球菌 2 2株 (6 .3% )。结论 肠球菌对替考拉宁、万古霉素、呋喃妥因的耐药率最低 ,粪肠球菌对氨苄西林和青霉素的耐药率相对较低 ,是临床首选的一类药 ,但对除粪肠球菌外的其他肠球菌应慎用氨苄西林和青霉素。屎肠球菌对氨苄西林和青霉素的耐药率较高 ,对氯霉素和四环素的耐约率相对较低 ,对于屎肠球菌 ,可选用氯霉素和四环素。肠球菌对庆大霉素、环丙沙星、链霉素的耐药率相对较高 ,应慎用 ,对红霉素的耐药率很高 。

Objective To investigate the drug resistance of 350 Enterococcus isolated in Guangzhou district. Methods The disk diffusion method was used and the surveillance results were analyzed according to the standard of NCCLS with control data. Results Totally 350 Enterococcus were isolated, including 279 Enterococcus faecalis (79.7%), 39 Enterococcus faeciums (11.1%), 10 Enterococcus aviums (2.9%) and 22 other Enterococcus (6.3%). Conclusions For Enterococcus , the resistance rates to teicoplanin, vancomycin and nitrofurantoin were the lowest; for Enterococcus faecalis, the resistance rates to ampicillin and penicillin were lower than the average, they should be the first selective drugs in clinical therapy; for the other Enterococcus except Enterococcus faecalis, ampicillin and penicillin should be carefully used in therapy; for Enterococcus faeciums , the resistance rates to ampicillin and penicillin were considerably high, the resistance rates to tetracycline and chloramphenicol were lower than the average, they could also be selected in therapy; for Enterococcus , the resistance rates to gentamicin, ciprofloxacin and streptomycin were considerably high, they should be carefully used in therapy. The resistance rate to erythromycin was the highest, it should not be used in therapy.