幽门螺旋杆菌与脑梗死相关性研究

Study of the correlation between Helicobacter pylori and cerebral infarction

目的探讨幽门螺旋杆菌(Hp)感染与脑梗死(CI)的相关性。方法选取51例初诊CI患者作为脑梗死组,49例门诊体检患者作为对照组。比较两组患者14碳尿素呼气试验阳性率。分别检测脑梗死Hp阳性组、脑梗死Hp阴性组及体检Hp阳性组患者血浆同型半胱氨酸(Hcy)水平进行比较。结果脑梗死组的Hp感染阳性率(64. 71%)明显高于对照组(57. 14%)。脑梗死Hp阳性组患者血浆同型半胱氨酸水平(35. 83±21. 85)μmol/L显著高于脑梗死Hp阴性组水平(25. 25±13. 02)μmol/L及体检Hp阳性组水平(18. 62±18. 48)μmol/L,且对比差异具有统计学意义(P <0. 01)。结论幽门螺旋杆菌与脑梗死有相关性。

Objective To investigate the correlation between Helicobacter pylori( Hp) infection and cerebral infarction( CI). Method 51 cases of cerebral infarction were selected for the first time as cerebral infarction group,and 49 healthy persons as the control group. Comparison of positive rates of 14 urea breath tests in two groups of patients.The plasma level of homocysteine( Hcy) in the Hp positive group of cerebral infarction,the Hp negative group of cerebral infarction and the Hp positive group of the physical examination were compared. Result The positive rate of Hp infection in the cerebral infarction group( 64. 71%) was significantly higher than that in the control group( 57. 14%). Cerebral infarction in Hp positive patients plasma homocysteine level( 35. 83 ± 21. 85) mol/L was significantly higher than that of cerebral infarction in Hp negative group level( 25. 25 ± 13. 02 mol/L) and Hp level examination positive group( 18. 62 ±18. 48 mol/L),and there was a significant difference( P < 0. 01). Conclusion Helicobacter pylori is associated with cerebral infarction.