早发型重度妊高征的临床研究

Clinical study on early onset severe pregnancy -induced hypertension

目的:探讨发生在较小妊周的重度妊高征之发生率、临床特征、治疗原则、终止妊娠时机及对母婴的影响。方法:选择妊娠≤34周的重度妊高征病例45例,按治疗方式的不同分成治疗组(遵循妊高征的治疗原则,同时给予营养支持和促胎肺成熟药物)和观察组。结果:两组病例均没有孕产妇死亡和子痫发生,但合并症、并发症的发生率高达95.24％。治疗组围产儿死亡率及发病率明显低于观察组。结论:早发型重度妊高征在终止妊娠前短期的保守治疗是安全有效的,给予积极治疗能明显减少围产儿死亡率、提高生存率。

Objective: To clarify the incidence, clinical characteristics , treatment, the time of pregnancy determination and maternal-fetal prognosis of early onset severe pregnancy-induced hypertension (PIH).Methods: Forty-five women who experienced severe pregnancy-induced hypertension diagnosed between 24 weeks and 34 weeks of gestation were enrolled and divided into two groups according to their treatment received. All the patients received routine regimes against PIH. Women in Group A received supportive treatment and regimes for promoting fetal maturity for three days or more, while women in Group B two days or less. Results: No maternal mortality and eclampsia were found in either group. 95. 24% women experienced a major complication. The fetal mortality and morbidity were lower in Group A than in Group B. Conclusion: Expectant management of early-onset severe PIH is safe and active therapy could decrease neonatal mortality and morbidity.