补肾调经方联合激素替代治疗卵巢早衰的临床研究

Clinical study on premature ovarian failure treated by Bushen Tiaojing Recipe combined with hormone replacement therapy

目的观察补肾调经方联合激素替代治疗(HRT)卵巢早衰(POF)的临床效果,为探索中药及中西医结合治疗POF患者安全有效的方法提供理论依据。方法将180例POF患者随机分成3组:中药组60例给予补肾调经方治疗,西药组60例给予HRT,中西药组60例给予补肾调经方配合HRT治疗; 3组患者均治疗6个疗程,治疗结束后随访6个月,比较3组患者治疗前、治疗结束时、停药6个月时主要症状及实验室检查包括卵泡刺激素(FSH)、雌二醇(E_2)、黄体生成素(LH)、血清抗苗勒管激素(AMH)水平,3组患者不良反应情况。结果与治疗前相比,治疗结束时及治疗结束后6个月3组患者的主要症状、实验室检查指标均有显著改善,差异均有统计学意义(P<0. 05);中、西药组优于中药组及西药组,差异有统计学意义(P<0. 05)。3组患者均未见明显不良反应。结论补肾调经方配合HRT治疗POF能明显改善患者的临床症状,是治疗POF的有效方法。

Objective To observe the clinical effect of Bushen Tiaojing Recipe combined with hormone replacement therapy(HRT)in treatment of premature ovarian failure(POF),provide a theoretical basis for safe and effective treatment of POF by traditional Chinese medicine and combined therapy of traditional Chinese medicine and western medicine.Methods A total of 180 patients with POF were randomly divided into three groups,60 patients in traditional Chinese medicine group were treated by Bushen Tiaojing Recipe,60 patients in western medicine group were treated by HRT,60 patients in combined therapy group were treated by Bushen Tiaojing Recipe combined with HRT.The patients in the three groups were treated for six courses of treatment.After treatment,the patients were followed up for six months.The main symptoms,laboratory examination results[follicle-stimulating hormone(FSH),estradiol(E2),luteinizing hormone(LH),serum anti-Müllerian hormone(AMH)],incidence rates of adverse reactions before treatment,at the end of treatment,at six months after drug withdrawal in the three groups were compared.Results Compared with before treatment,the main symptoms and laboratory examination indicators were improved significantly at the end of treatment and at six months after drug withdrawal in the three groups(P<0.05),the improvements in combined therapy group were statistically significantly better than those in traditional Chinese medicine group and western medicine group(P<0.05).No obvious adverse reactions were observed in the three groups.Conclusion Bushen Tiaojing Recipe combined with HRT can significantly improve clinical symptoms of POF patients,which is an effective method in treatment of POF.