国产尿源FSH和重组FSH在IVF/ICSI-ET早卵泡期长方案COH中的疗效比较

Comparison of efficacy of domestic urinary follicle-stimulating hormone and recombinant follicle-stimulating hormone in IVF/ICSI-ET early follicular phase long regimen for superovulation

目的探讨国产尿源FSH和重组FSH应用于体外受精/卵泡浆内单精子显微注射—胚胎移植(IVF/ICSI-ET)早卵泡期长方案超促排卵(COH)中的临床疗效。方法选取2014年6月-2018年1月在该院生殖中心行早卵泡期长方案的183例患者为研究对象,按照Gn用药不同分为国产尿源FSH (58例)和重组FSH (125例),评估两组患者的获卵及临床妊娠结局。结果国产尿源FSH组患者的获卵数与重组FSH组比较,差异无统计学意义(P>0. 05),两组患者的Gn用量及天数、优质胚胎数、临床妊娠率、早期流产率、周期取消率以及中重度卵巢过度刺激综合征(OHSS)发生率比较,差异均无统计学意义(均P>0. 05)。结论在IVF/ICSI-ET早卵泡期长方案COH中应用国产尿源FSH并不影响妊娠结局,且存在价格优势。

Objective To investigate the clinical efficacy of domestic urinary follicle-stimulating hormone and recombinant follicle-stimulating hormone in the long down-regulation protocol of early follicular phase for IVF/ICSI-ET.Methods 183 patients with early follicular phase in the reproductive center of Binzhou Medical College Affiliated Hospital were divided into 58 cases of domestic u FSH group and125 cases of r FSH group according to different Gn medications.The results of oocyte retrieval numbers and clinical pregnancy rates in two groups were analyzed.Results The number of oocytes obtained in the domestic u FSH group was not significantly different from that in the r FSH group(P>0.05).The Gn dose and days,number of high-quality embryos,clinical pregnancy rates,abortion rates,cycle cancellation rates,and moderate-to-severe Ovarian hyperstimulation syndrome(OHSS)were not statistically significant between the two groups(P>0.05).Conclusion The use of domestic u FSH and r FSH does not affect the outcome of pregnancy in IVF/ICSI-ET in the treatment of early follicular phase,furthermore,there was a price advantage.