重组β细胞营养因子在妊娠期糖尿病患者发病中的作用被引量：5

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摘要目的研究重组β细胞营养因子对妊娠期糖尿病患者肾间质炎症的影响。方法收集2014年1月-2017年1月武汉科技大学附属汉阳医院妇产科收治的妊娠期糖尿病并发肾间质炎症的患者58例为观察组,收集定期来本院产检的健康孕妇60例为对照组。比较两组孕妇的血清重组β细胞营养因子、血糖代谢指标(主要包括胰岛素抵抗指数HOMA-IR、Matsuda指数和胰岛素功能敏感指数HOMA-β等)、肾间质炎症相关指标(尿IL-8、尿IL-1β、尿蛋白总量及肾小球率过滤eGFR等)水平,研究妊娠期糖尿病并发肾间质炎症患者的重组β细胞营养因子与其肾间质炎症的相关性。结果两组孕妇年龄差异无统计学意义(P>0. 05);观察组患者BMI明显高于对照组,腰围明显大于对照组,血清Betatrophin明显高于对照组,HOMA-β明显低于对照组,HOMA-IR明显高于对照组,Matsuda指数明显低于对照组,差异均有统计学意义(P<0. 05)。观察组孕妇尿IL-8水平、尿IL-1β水平、尿蛋白总量明显高于对照组,eGFR水平明显低于对照组,差异均有统计学意义(P<0. 05)。妊娠期糖尿病孕妇血清Betatrophin水平与糖代谢指标HOMA-IR、尿IL-18、尿IL-1β及尿蛋白总量呈正相关(P<0. 05),与糖代谢指标HOMA-β、Matsuda指数及eGFR呈负相关(P<0. 05)。结论重组β细胞营养因子在妊娠期糖尿病患者体内高水平表达,血清Betatrophin水平与糖代谢指标HOMA-IR、尿IL-18、尿IL-1β及尿蛋白总量呈正相关,与糖代谢指标HOMA-β、Matsuda指数及eGFR呈负相关,Betatrophin与GDM患者肾间质炎症有密切关系。

作者张远远胡昌华赵方

机构地区武汉科技大学附属汉阳医院

出处《中国妇幼保健》 CAS 2019年第20期4660-4663,共4页 Maternal and Child Health Care of China

关键词重组β细胞营养因子妊娠期糖尿病肾间质炎症

分类号 R714.256 [医药卫生—妇产科学]

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