自拟和胃理气方联合雷贝拉唑治疗胆汁反流性胃炎:一项随机对照研究

Analysis on the Treatment of Ziniheweiliqifang Combined with Rabeprazole on Bile Reflux Gastritis: a Randomized Controlled Trails

目的探讨自拟和胃理气方联合雷贝拉唑治疗胆汁反流性胃炎的临床疗效。方法采取随机数表法将我院诊治的140例胆汁反流性胃炎患者分为对照组和实验组,每组各70例。对照组采用雷贝拉唑联合铝碳酸镁治疗,实验组采用自拟和胃理气方联合雷贝拉唑和铝碳酸镁治疗,两组均治疗4周。根据两组症状严重程度评分、胃镜检查所见结果和症状改善情况作为疗效评定和临床观察的指标。结果实验组临床总有效率为92.9%,对照组临床总有效率为62.9%,实验组优于对照组(P<0.05);两组治疗后腹痛、腹胀、嗳气、口苦、恶心和呕吐积分均显著降低(P<0.05),且实验组上述积分均显著低于对照组(P<0.05);实验组患者治疗后胃镜检查疗效明显高于对照组(P<0.05)。结论自拟和胃理气方联合雷贝拉唑治疗胆汁反流性胃炎的疗效显著,能够缓解患者痛苦,且无严重不良反应,值得推广应用。

OBJECTIVE To evaluate the treatment of Ziniheweiliqifang combined with Rabeprazole on bile reflux gastritis. METHOD There were 140 patients with bile reflux gastritis in our hospital, randomly divided into 2 groups: 70 cases in experimental group weretreated by Ziniheweiliqifang combined with rabeprazole and magnesium aluminum carbonate; 70 cases in control group were treatedrabeprazole and magnesium aluminum carbonate, two groups were treated for 4 weeks. According to the two groups, the results of thegastroscopy and the improvement of the symptoms were used as the indexes of the evaluation of the curative effect and the clinical ob-servation. RESULTS The clinical total efficiency of experimental group was 92.9%, 62.9% in the control group, the experimentalgroup was better than the control group(P<0.05); the two groups after treatment of abdominal pain, abdominal distension, belching,nausea, vomiting, pain scores were significantly lower(P<0.05), and the symptom scores of experimental group were significantly lowerthan the control group(P<0.05); the two groups after treatment, gastroscopy efficacy of the experimental group was significantly higherthan the control group(P<0.05). CONCLUSION Zinihewei Liqifang combined with rabeprazole is effective in treating bile reflux gastri-tis, relieving patients' pain and no serious side effects, which was worthy of promotion.