自拟消疣汤联合干扰素a-2b凝胶治疗宫颈HPV感染癌前病变及对术后复发的效果分析

Analysis on the Effect of Wu Teng Decoction Combined with Interferon a-2b gel in the Treatment of Precancerous Lesions of Cervical HPV Infection and Its Effect on Postoperative Recurrence

目的观察自拟消疣汤联合干扰素a-2b凝胶治疗宫颈HPV感染癌前病变患者的治疗效果和术后复发预防效果。方法选取2014年6月—2017年6月上海市静安区闸北中心医院收治的宫颈HPV感染癌前病变及手术治疗的患者68例,随机分为研究组和对照组,每组各34例。对照组患者给予单纯干扰素a-2b凝胶治疗,研究组患者给予自拟消疣汤联合干扰素a-2b凝胶治疗,对两组的治疗效果和术后复发情况进行比较分析。结果研究组治疗总有效率为91.2%,明显高于对照组的67.7%,差异有统计学意义(P<0.05);两组治疗后中医症候总积分和RLU/CO值均较治疗前明显降低,与对照组比较,研究组降低更显著,差异有统计学意义(P<0.05);研究组HPV病毒转阴率为82.3%,明显高于对照组的55.9%,差异有统计学意义(P<0.05);治疗后,研究组复发率(3.0%)与对照组复发率(20.6%)比较明显降低,差异有统计学意义(P<0.05)。结论采用自拟消疣汤联合干扰素a-2b凝胶治疗宫颈HPV感染癌前病变能够取得显著的临床疗效,且术后复发率低,值得临床推广应用。

OBJECTIVE To observe the curative effect and preventive effect of self-made wuteng decoction combined with interferon a-2 b gel in the treatment of precancerous lesion of cervical HPV infection. METHODS 68 patients with cervical precancerous lesionsand surgical treatment of cervical HPV infection in target hospital from June 2014 to June 2017 were randomly divided into studygroup and control group, with 34 cases in each group. Patients in the control group were treated with interferon alfa-2 b gel alone. Pa-tients in the study group were given self-made wushen decoction combined with interferon alfa-2 b gel treatment, and the clinical effi-cacy and postoperative recurrence were compared between the two groups. RESULTS The total effective rate of study group was91.2%, which was significantly higher than that of control group(67.7%), the difference was statistically significant(P<0.05); aftertreatment, the total score of Chinese medicine symptom and RLU/CO value were significantly lower than those before treatment, Com-pared with the control group, the study group decreased more significantly, the difference was statistically significant(P<0.05); thestudy group HPV negative conversion rate was 82.3%, Which was significantly higher than the control group, 55.9%, the differencewas statistically significant(P<0.05). After treatment, the recurrence rate of the study group(3.0%) was significantly lower than thatof the control group(20.6%), the difference was statistically significant(P<0.05). CONCLUSIONS The self-made Xiao Tong Decoc-tion combined with IFN-α-2 b gel ould achieve significant clinical effect in cervical precancerous lesions of HPV infection, and thepostoperative recurrence rate is low, which wasw worthy of clinical promotion and application.