超快激光制备生物医用材料表面功能微结构的现状及研究进展

Surface functional microstructure of biomedical materials prepared by ultrafast laser: a review

提高医疗植入材料的生物相容性,对提升植入医疗器械的安全性有重要意义。通过超快激光制造出微纳米级别尺寸的材料结构以改善材料的生物相容性,近年来已被广泛应用于生物医学领域。本文简单介绍了细胞与生物材料相互作用原理,从生物材料表面微结构对其生物相容性能的影响出发,综述了超快激光加工不同材料表面形貌特征对细胞粘附、迁移、增殖、分化的影响,并进一步指出超快激光制备微纳结构在生物材料领域的局限和发展趋势。

Improvements to the biocompatibility of medical implant biomaterials have a great significant impacttoward improving the safety of the implants.Ultrafast lasers have been widely used in biomedical sciences for their ability to produce micro/nano structures that improve the biocompatibility of biomaterials.In this paper,mechanisms of interaction between cell and biomaterials are briefly introduced.The effects of surface topography on cell adhesion,migration,multiplication and differentiation are summarized according to the effect of surface structure on the biocompatibility.The disadvantages of current laser microfabrication technologies in biomaterials are identified and suggestions for further development are provided.