乙型肝炎病毒宫内感染的研究

Study on Intra-uterine Infection of Hepatitis B Virus

为了调查乙型肝炎病毒感染后宫内感染情况和胎儿的免疫反应,我们检查了17名 HBsAg 阳性的孕妇和她们生的17名婴儿的 HBV 血清学标志。结果17名母亲静脉血 HBsAg 滴度1∶16—1∶512,仅有一名新生儿的脐血 HBsAg 阳性,滴度是1∶32,8名和1名母亲的 HBeAg 和抗-HBe 分别是阳性。2名 HBe Ag 阳性母亲所生新生儿脐血 HBeAg 阳性。2名新生儿抗-HBe 阳性,其中有一名的母亲抗-HBe 亦是阳性。共有16名母亲和12名新生儿抗-HBc 阳性,13名母亲和7名新生儿抗-HBc·IgM 是阳性。在抗-HBc·IgM 阴性的孕妇中,HBeAg 可能是 HBV 宫内感染的重要因素。

Serological markers of hepatitis B were exami- ned in 17 HBsAg positive pregnant women and their 17 newborns in order to investigate the intra- uterine HBV infection and immunological reactions of fetus after HBV infection.The results indicated that the HBsAg titers of venous blood of 17 mo- thers were 1:16～1:512 and the cord blood of only one newborn was HBsAg positive with a titer of 1 32.HBeAg and anti-HBe were positive in 8 and 1 mothers respectively.Two newborns born from 2 HBeAg-positive mothers had their cord blood po- sitive for HBeAg.Two newborns were found to be anti-HBe positve bat one of their mothers was anti- HBe-positive.Total anti-HBc was positive in 16 mothers and 12 newborns,while IgM anti-HBc was positive in 13 mothers and 7 newborns.It is con- sidered that HBeAg may be the important factor of intra-uterine HBV infection and the possibility of intra-uterine HBV infection is very low in IgM anti- HBc negative pregnant women.