京西地区451例煤工尘肺合并慢性阻塞性肺疾病情况调查

Investigations of 451 Coal Worker's Pneumoconiosis complicated with COPD in Western District of Beijing

目的了解煤工尘肺合并慢性阻塞性肺疾病(简称慢阻肺)的患病情况及其高危因素、临床症状特点、用药情况。方法收集京西地区451例煤工尘肺作为研究对象,对受试者进行肺功能测定,并收集其一般资料,包括临床症状、用药,应用多因素回归分析法分析各种危险因素对尘肺患者罹患慢阻肺的作用。结果尘肺患者中慢阻肺患病率为44.6%。随着尘肺期别、接尘时间、吸烟指数的增加,尘肺患者慢阻肺患病率相应增高,其OR值分别为3.20、1.09和1.01。合并慢阻肺者CAT评分均值为25.6。煤工尘肺合并慢阻肺患者症状重,用药不规范。结论煤工尘肺患者中慢阻肺患病率明显高于普通人群;接尘时间、吸烟指数、煤工尘肺期别为其合并慢阻肺的高危因素。合并慢阻肺的患者症状重,用药不规范。

Objective To understand the prevalence,risk factors,clinical features and the medication of coal worker's pneumoconiosis( CWP) complicated with chronic obstructive pulmonary disease( COPD). Methods Pulmonary function testing results,clinical symptoms,medication of 451 patients with CWP were collected. Then,the risk factors relevant to the incidence of COPD in CWP were analyzed with Cox multivariate regression. Results The prevalence of COPD in CWP was 44. 6%,and the incidence was rising with the increasing of CWP phases,exposure duration,smoking index,with the odds ratio of 3. 20,1. 09,and 1. 01,respectively. The patients with CWP and COPD were suffered more symtoms with a CAT score of 25. 5 but received less regular medications. Conclusions The incidence of COPD in CWP is obviously higher than that in common populaton. Exposure duration,smoking index and phases of CWP are the high risk factors for COPD in the population of CWP. The patients with CWP and COPD are suffered more symtoms but receive irregular medications.