病毒感染引起的细胞器应激损伤和选择性自噬

Virus Infection Causes Cell Organelle Stress and Selective Autophagy

病毒感染细胞是对细胞的一种征服和利用行为,通常会引起细胞的一系列应激反应,特别是细胞器的应激反应尤为激烈,这种持续的应激反应不可避免地造成细胞器的损伤。病毒利用了细胞自身的胞内环境稳态维持机制,对损伤的细胞器进行选择性自噬,再与溶酶体融合降解它们,而降解后形成的生物基质又成为病毒组分生物合成所需要的原始材料,从而为病毒复制服务。

Virus infection is a kind of conquest and utilization of cells,which usually causes series stress reactions in infected cells.In particular,the responses lead to the damage of organelles.Autophagy is the intracellular homeostasis maintenance mechanism of cells.Viruses use autophagy to selectively autophagy damaged organelles to prevent premature apoptosis,which is not conducive to virus replication.And substrate degradation after the formation of creatures become virus biosynthesis needed materials,components and services for viral replication.