期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

亚甲基四氢叶酸还原酶(MTHFR)C677T基因多态性与血压变化的相关性研究

Relevant research on methylenetetrahydrofolate reductase(MTHFR) C677T gen polymorphism and blood pressure change
下载PDF
导出
摘要 高血压和高同型半胱氨酸血症是冠状动脉粥样硬化性心脏病(简称冠心病CVD)的独立危险因素。同型半胱氨酸浓度主要受亚甲基四氢叶酸还原酶(MTHFR)C677T基因多态性的影响,尤其受纯合子(即TT基因型)的影响。本综述旨在研究MTHFR C677T基因多态性与血压变化的关系。 High blood pressure and hyperhomocysteinemia(HHcy) are independent risk factors for coronary atherosclerotic heart disease(CVD).Homocysteine concentration is mostly affected by methylenetetrahydrofolate reductase(MTHFR) C677T gene polymorphism,especially by homozygote(TTgenotype).The paper aims to study the relationship between MTHFR C677T gene polymorphism and blood pressure change.
作者 侯志峰
机构地区 济南军区青岛第一疗养院
出处 《中国疗养医学》 2016年第8期804-806,共3页 Chinese Journal of Convalescent Medicine
关键词 亚甲基四氢叶酸还原酶 C677T基因多态性 同型半胱氨酸 Methylenetetrahydrofolate reductase(MTHFR) C677T gene polymorphism Homocysteine
分类号 R544.1 [医药卫生—心血管疾病] R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献12

  • 1靳钰,赵连友,侯允天,王志方.亚甲基四氢叶酸还原酶基因多态性与原发性高血压患者合并冠心病的相关性研究[J].中华老年心脑血管病杂志,2011,13(12):1081-1083. 被引量：13
  • 2唐仪,陈慧,吴小盈,骆杰伟.N^(5，10)-亚甲基四氢叶酸还原酶基因多态性与原发性高血压病的关系研究[J].中国分子心脏病学杂志,2007,7(4):205-207. 被引量：13
  • 3Osvaldo Fridman,Rafael Porcile,Virginia Vanasco,Mariano N. Junco,Luis Gariglio,Miguel A. Potenzoni,Isabel Ba?,es,Analí,a Morales.??Study on Homocysteine Levels and Methylenetetrahydrofolate Reductase Gene Variant (C677T) in a Population of Buenos Aires City(J)Clinical and Experimental Hypertension . 2008 (7)
  • 4Yi, Fan,Li, Pin-Lan.??Mechanisms of Homocysteine-Induced Glomerular Injury and Sclerosis(J)American Journal of Nephrology . 2008 (2)
  • 5Hisahide Nishio,Myeong Jin Lee,Motoko Fujii,Kazuomi Kario,Kazunori Kayaba,Kazuyuki Shimada,Masafumi Matsuo,Kimiaki Sumino.??A common mutation in methylenetetrahydrofolate reductase gene among the Japanese population(J)The Japanese Journal of Human Genetics . 1996 (2)
  • 6M. Guillén,D. Corella,O. Portolés,J.I. González,F. Mulet,C. Sáiz.??Prevalence of the methylenetetrahydrofolate reductase 677C > T mutation in the Mediterranean Spanish population. Association with cardiovascular risk factors(J)European Journal of Epidemiology . 2001 (3)
  • 7Methylenetetrahydrofolate Reductase Polymorphism, Type II Diabetes Mellitus, Coronary Artery Disease, and Essential Hypertension in the Czech Population(J)Molecular Genetics and Metabolism . 2001 (2)
  • 8Francisco Rodríguez‐Esparragón,Octavio Hernández‐Perera,José C. Rodríguez‐Pérez,Aránzazu Anabitarte,Juan M. Díaz‐Cremades,Antonio Losada,Dolores Fiuza,Enrique Hernández,Carla Yunis,Carlos M. Ferrario.??The Effect of Methylenetetrahydrofolate Reductase C677T Common Variant on Hypertensive Risk Is Not Solely Explained by Increased Plasma Homocysteine Values?(J)Clinical and Experimental Hypertension . 2003 (4)
  • 9Nozomu Inamoto,Tomohiro Katsuya,Yoshihiro Kokubo,Toshifumi Mannami,Takashi Asai,Shunroku Baba,Jun Ogata,Hitonobu Tomoike,Toshio Ogihara.??Association of Methylenetetrahydrofolate Reductase Gene Polymorphism With Carotid Atherosclerosis Depending on Smoking Status in a Japanese General Population(J)Stroke: Journal of the American Heart Association . 2003 (7)
  • 10P. Bogdanski,D. Pupek-Musialik,J. Dytfeld,M. Lacinski,A. Jablecka,H. Jakubowski.Plasma homocysteine is a determinant of tissue necrosis factor-α in hypertensive patients[J]. Biomedicine & Pharmacotherapy . 2007 (6)

二级参考文献13

  • 1Verdecchia P, Reboldi G,Gattobigio R, et al. Atrial fibrillation in hypertension: predictors and outcome. Hypertension, 2003, 41:218-223.
  • 2Frosst P, Blom H J, Milos R, et al. A candidate genetic risk factor for vascular disease: a corn mon mutation in methylenetetrahydrofolate reductase. Nat Gene, 1995,10: 111-113.
  • 3Conen D,Cheng S, Steiner LL, et al. Association of 77 poly morphisms in 52 candidate genes with blood pressure progres sion and incident hypertension: the Women, s Genome Health Study. J Hypertens, 2009,27 : 476-483.
  • 4Muniz MT, Siqueira ER, Fonseea RA, et al. Evaluation of MTHFR C677T gene polymorphism and homocysteine level in coronary atherosclerotic disease. J Arq Bras Endocrinol Metabol, 2006,50: 1059-1065.
  • 5唐仪,陈慧,吴小盈,骆杰伟.N^(5，10)-亚甲基四氢叶酸还原酶基因多态性与原发性高血压病的关系研究[J].中国分子心脏病学杂志,2007,7(4):205-207. 被引量：13
  • 6Nagahama K,Inoue T,Iseki K,et al.Hyperuricemia as a predictor of hypertension in a screened cohort in Okinawa,Japan[].Hypertension Research.2004
  • 7Huh HI,Chi HS,Shim EH,et al.Gene-nutrition interactions in coronary artery disease:correlation between the MTHFR C677T pol- ymorphism and folate and homocysteine status in a Korean popula- tion[].Thrombosis Research.2006
  • 8Goyette P,Sumner JS,Milos R,et,al.Human methylinetetra- hydrofolate reductase:isolation of eDNA,mapping and mutation i- dentification[].Nature Genetics.1994
  • 9Hong YS,Lee MJ,Kim KH,et al.The C677T mutation in methyl- ene tetrahydrofolate reductase gene:correlation with uruci acid and cardiovascular risk factor in elderly Koream men[].Koream Med Sci.2004
  • 10Feig DI,Mazzali M,Kang DH,et al.Serum uric acid:a risk factor and a target for treatment[].Journal of the American Society of Nephrology.2006

共引文献25

中国疗养医学
2016年 第8期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部