降钙素原与D-二聚体在评估脓毒症及脓毒性休克患者病情及预后中的价值

Value of calcitonin and D-dimmer on the disease assessment and prognosis of patients with sepsis and sepsis shock

目的探讨降钙素原与D-二聚体在急诊脓毒症患者病情评估及预测预后中的作用。方法在患者确诊后24 h内检测D-二聚体含量及降钙素原浓度,探讨D-二聚体联合降钙素原检测患者的病情严重程度。以患者临床死亡或存活为观察终点,将患者分为存活组及死亡组,对两组患者D-二聚体、降钙素原指标进行比较,记录入院24 h急性生理与慢性健康状况(APACHEⅡ)评分。结果死亡组患者降钙素原、D-二聚体水平及APACHEⅡ评分明显高于存活组,差异有高度统计学意义(P<0.01),脓毒症患者降钙素原、D-二聚体水平及APACHEⅡ评分均明显低于脓毒性休克患者,组间比较,差异有高度统计学意义,P<0.01。降钙素原与D-二聚体水平与患者预后呈正相关,降钙素原与D-二聚体水平越高,死亡风险越高。结论降钙素原与D-二聚体可有效评估脓毒症患者的病情程度,并可预测患者的预后。

Objective To explore the value of calcitonin and D-dimmer on the disease assessment and prognosis of patients with sepsis under emergency treatment.Me thods The content of D-dimmer and the concentration of calcitonin of patients were tested within 24 hours after they were diagnosed with sepsis to explore their value in determining the severity into the live group and the dead group.The indexes of calcitonin and D-dimmer were compared between the two groups and their APACHEⅡscores were recorded within 24 hours after their admission into the hospital.Re s ults The levels of calcitonin and D-dimmer and APACHEⅡscores of the dead group were significantly higher than those of the live group and the difference was of statistical significance(P<0.01).The levels of calcitonin and D-dimmer and APACHEⅡscores of the sepsis patients were significantly lower than those of patients with sepsis shock.The difference showed significant statistical significance between groups(P<0.01).The levels of calcitonin and D-dimmer were positively correlated with the prognosis of patients.The higher the levels of calcitonin and D-dimmer,the higher the risk of death.Conclus ion Calcitonin and D-dimmer could effectively assess the disease severity of patients with sepsis and predict their prognosis.