摘要
目的:对左氧氟沙星(LVFX)和多索茶碱(Dox)合用在大鼠体内的药代动力学进行研究。方法:用胶束电动毛细管电泳法(MECC)检测Dox的血药浓度。结果:单用和合用Dox均符合二房室模型。单用和合用Dox的药代动力学参数,K_(21)为(25.78±0.37)h^(-1)和(25.35±0.59)h^(-1);K_(12)为(12.00±2.02)h^(-1)和(10.75±2.16)h^(-1);K_(10)为(0.42±0.03)h^(-1)和(0.41±0.04)h_(-1);t_(1/2α)为(0.02±0.001)h和(0.02±0.001)h;t_(1-2β)为(2.43±0.10)h和(2.38±0.10)h;Vc为(1.58±0.38)L/kg和(1.57±0.29)L/kg;AUC为(112.39±35.05)μg·h/mL和(111.38±28.80)μg·h/mL;CLs为(0.67±0.16)L/h和(0.66±0.14)L/h。两组各参数比较,P均大于0.05。结论:在大鼠体内LVFX对Dox的药代动力学无显著影响。
Objective: To study the pharmacokinetics of doxophylline(Dox) combined with levofloxacin(LVFX) in rats. Methods: The Dox concentration in plasma was delected by high performance capillary electrophoresis(HPCE) method. Results: The plasma drug concentration-
time curves of Dox in rats were adequately fitted to two-compartment open model. The pharmacokinetic parameters of Dox alone and combined groups in rats were: K21 (25. 78±0. 37 )h-1 and (25.35±0.59) h1: K12 (12.00 ±2.02)h-1 and (10. 75±2. 16)h-1; K10 (0.42±0. 03)h-1 and (0. 41±0.04)h-1;t1/2α(0. 02±0. 001 )h and (0. 02 ±0. 001 )h;t1/2β (2. 43±0. 10)h and (2. 38 ±0. 10)h; Vc(1. 58±0. 38 )L/kg and (1.57±0.29)L/kg; AUC (112.39±35.05)μg·h/mL and (111. 38±28.80)μg· h/mL; CLs (0. 67±0. 16)L/h and (0.66±0.14)L/h(P >0. 05) in every group. Conclusion: LVFX had no apparent influence on pharmacokinetics of Dox in rats.
出处
《中国药业》
CAS
2004年第1期42-43,共2页
China Pharmaceuticals
