肝癌术后复发的多学科综合治疗

Multidisciplinary comprehensive treatment of postoperative recurrence of hepatocellular carcinom

复发性肝癌的治疗手段主要包括再次手术切除、肝移植、局部消融治疗、介入治疗、靶向治疗以及全身化疗等,但由于复发性肝癌病情复杂,单一治疗效果并不满意,多学科综合治疗是其必然选择,目前比较常用的联合治疗方式主要有经皮肝动脉化疗栓塞(TACE)+外科治疗、TACE+局部治疗、TACE+全身治疗等。临床上应以延长生存和保证生存质量为目的,针对不同病人的肝脏情况、全身状况以及肿瘤复发情况选择不同的多学科联合治疗方案,可显著延长病人的生存时间。

The treatment modality of recurrent hepatocellular carcinoma(HCC)includes surgical resection,liver transplantation,ablation,interventional therapy,targeted therapy,and systemic chemotherapy.However,the complexity of disease condition often leads to unsatisfying outcome by single treatment,making multidisciplinary treatment an inevitable choice.Commonly used combined therapies are transarterial chemoembolization(TACE)combined with surgical resection,TACE combined with local ablation,and TACE combined with systemic treatment.In clinical practice,the goal of comprehensive treatment is prolonged survival and improved quality of life.Choosing different combination of therapies according to different liver function,general condition and recurrence of tumors can significantly improve the patients’survival.