血清PCT和CRP检测在社区获得性细菌性肺炎中的应用价值

Clinical value of procalcitonin and C-reactive protein in community acquired bacterial pneumonia

目的探讨血清降钙素原(PCT)和C-反应蛋白(CRP)在社区获得性细菌性肺炎(CAP)中的应用价值。方法收集2010年1月至2012年12月该院社区获得性肺炎患者,比较细菌性和非细菌性患者血清CRP和PCT浓度的变化,探讨血清CRP和PCT浓度水平在社区获得性肺炎鉴别诊断中的价值。结果细菌性CAP患者中CRP水平可达(62.73±15.36)mg/L,PCT水平可达(9.35±4.02)μg/L,较非细菌性CAP患者明显升高,两者间差异具有统计学意义(P<0.05)。血清CRP和PCT浓度在细菌性CAP诊断中的ROC曲线下面积分别为0.854和0.835,对细菌性CAP的诊断具有良好的特异性和敏感度。结论血清CRP和PCT水平在细菌性CAP的鉴别诊断中具有重要的临床价值,可用于病原诊断、病情评估和预后判断。

Objective To explore the clinical diagnostic value of procalcitonin( PCT) and C-reactive protein( CRP) in bacterial community acquired pneumonia( CAP). Methods We included patients suffering from community acquired pneumonia from January 2010 to December 2012 in our hospital. The serum CRP and PCT levels were compared between patients diagnosed as bacterial CAP and those with non-bacterial CAP. Results The level of CRP was( 62. 73 ± 15. 36) mg / L and that of PCT was( 9. 35 ± 4. 02) μg / L in patients with bacterial CAP, which were significantly higher than those in patients with non-bacterial CAP( P < 0. 05). The area under ROC curve was 0. 854 for CRP and 0. 835 for PCT in bacterial CAP patients,which showed good sensitivity and specificity for bacterial CAP. Conclusion The serum CRP and PCT have a good clinical diagnostic value for bacterial CAP,which could be used in pathogen diagnosis,assessment and prognosis.