综合性医院与妇幼医院金黄色葡萄球菌药敏比较

Drug sensitivitity of Staphylococcus aureus in Jiaxing area: a comparison between General Hospital and the Maternity and Child Health Care Hospital

目的对综合性医院及妇幼保健院的金黄色葡萄球菌(SA)药敏结果进行分析比较,为临床使用抗菌素治疗提供科学依据。方法用法国梅里埃VITEK 32鉴定仪及其配套试剂进行鉴定和药敏试验。手工药敏试验选择纸片扩散法。结果 SA对万古霉素、利奈唑烷均敏感,青霉素G耐药率在95%左右。多种抗菌素的药敏结果比较差异有统计学意义,P值均<0.05。结论金黄色葡萄球菌引起的感染,应根据不同感染人群,可先根据经验选择抗菌素,药敏结果出来后再行调整,以减少耐药菌株的出现。

Objective To compare the drug sensitivity of Staphylococcus aureus between a general hospital and Maternal and Child Health Care Hospital,and provide scientific foundation for the rational use of antibiotics. Methods France Bio-merieux VITEK 32 and its specific reagents were used to identify bacteria and determine drug sensitivity. Kirby-Bauer method was used as manual susceptibility test. Results To vancomycin and linezolid,the sensitivity rates were 100%. The resistance rates to Penicillin G were about 95%. There were significant differences in the susceptibilities to many antibiotics between the two hospitals( P < 0. 05). Conclusion It is essential to choose reasonably antimicrobial agents according to antimicrobial susceptibility test results for treatment of infections caused by Staphylococcus aureus,so as to reduce the emergence of resistant strains.