阴道微生态与宫颈疾病发生发展的相关性研究

The role of vaginal microbiota in cervical disease:Research progress

微生态学是近年新兴的学科,女性生殖道是一个重要的微生态区域。生殖道微生态体系是由正常的解剖结构、生殖道各种菌群、周期性内分泌变化、局部免疫系统四个部分组成。随着阴道微生态平衡理论的提出和发展,阴道微生态和HPV感染、宫颈上皮内瘤变、宫颈癌的内在关联引起了极大的重视。阴道微生态与宫颈疾病的发生发展相关,宫颈病变影响了阴道微生态环境,长期的阴道菌群失调也会反作用于宫颈,导致宫颈的病变加重甚至恶化,如此形成恶性循环。因此阴道微生态对宫颈疾病的诊断、治疗和预防将具有重要的临床意义。

Microecology is an emerging discipline in recent years.The female reproductive tract is an important microecological area,including the normal anatomical structures,diversities of microbial communities,periodic endocrine changes and local immune system.With the development of vaginal microecology,people pay great attention to the internal relations between vaginal microecology and cervical diseases such as HPV infection,cervical intraepithelial neoplasia and cervical cancer.Vaginal microecology is associated with the progression of cervical diseases which affect vaginal microecology,and vaginal dysbacteriosis will react on the cervix,leading to the deterioration of the cervical diseases.Vaginal microecology will have important clinical significance for the diagnosis,treatment and prevention of cervical diseases.