双歧杆菌三联活菌散联合葡萄糖酸锌对儿童厌食症患者的疗效及其肠道菌群的影响

The effect of Bifid-Triple Viable Powder combined with Zinc Gluconate on intestinal flora of children with infantile anorexia

目的探讨双歧杆菌三联活菌散联合葡萄糖酸锌对儿童厌食症患者的疗效及其肠道菌群的影响。方法选取儿科门诊就诊的儿童厌食症患者80例,随机分为观察组和对照组各40例。两组患儿均予以调整饮食习惯及健胃消食药治疗。对照组患儿加用葡萄糖酸锌口服液10 mL/次,1次/d,口服。观察组患儿在对照组基础上加用双歧杆菌三联活菌散1.0～2.0 g/次,3次/d,温开水冲服。两组患儿均连用8周。观察并比较两组患儿治疗前后微量元素(铁和锌)及肠道菌群(乳杆菌、双歧杆菌和肠杆菌)的变化,并评估其临床效果。结果治疗8周后,两组患儿血清铁和锌含量均不同程度上升(P<0.05),且观察组上升幅度较对照组更显著(P<0.05)。治疗后观察组患儿肠道乳杆菌和双歧杆菌数量明显上升,肠杆菌数量明显下降(P<0.05),而对照组患儿治疗前后肠道菌群数量变化无统计学意义(P>0.05)。治疗后观察组患儿肠道乳杆菌和双歧杆菌数量高于对照组,肠杆菌数量低于对照组(P<0.05),同时观察组患儿临床总有效率(95.00%)高于对照组(80.00%)。结论双歧杆菌三联活菌散联合葡萄糖酸锌对儿童厌食症患者的疗效确切,能增进患儿食欲和食量,其机制可能与其能能调节肠道菌群紊乱,改善患儿肠道微生态环境,促进肠道对铁和锌等微量元素的吸收和利用密切相关。

Objective To explore the effect of Bifid-Triple Viable Powder combined with Zinc Gluconate on intestinal flora of children with infantile anorexia.Methods 80 children with infantile anorexia were selected and divided into observation group or control group at random,with 40 cases in either group.Both groups were given diet habit adjustment and drugs to improve digestion,as well as Zinc Gluconate oral liquid 10 mL qd;the children in observation group were additionally given Bifid-Triple Viable Powder 1.0 to 2.0 g tid,for 8 weeks.The changes in microelement levels(iron and zinc)and intestinal flora(Lactobacilli,Bifidobacteria and Enterobacters)of children in both groups were observed and compared,and the clinical efficacy was evaluated.Results After 8 weeks of treatment,the levels of serum iron and zinc in both groups obviously rose(P<0.05),with the rising rates in observation group much higher than those in control group(P>0.05).The quantities of Lactobacilli and Bifidobacteria of patients obviously rose while that of Enterobacters obviously declined in observation group after treatment(Ps<0.05);no obvious changes appeared in control group(P<0.05).The quantities of Lactobacilli and Bifidobacteria were much higher while that of enterobacters much lower in observation group than those in control group respectively after treatment(Ps<0.05).The total clinical efficiency in observation group(95.00%)was higher than that in control group(80.00%).Conclusion Bifid-Triple Viable Powder combined with Zinc Gluconate has reliable efficacy on infantile anorexia,and can improve appetite and intake,the mechanism of which may closely relate to its effects of adjusting the disorder of intestinal flora,improving intestine microenvironment and raising the absorption and utility of iron,zinc and other microelements of children.