肿瘤坏死因子α与白细胞介素6和白细胞介素10及相关信号通路在类风湿关节炎合并抑郁症中的研究进展

Research progress of tumor necrosis factor-α,interleukin-6/-10 and related signal transduction pathways in rheumatoid arthritis with depression

类风湿关节炎(RA)是一种以某些促炎性细胞因子过度分泌为特征的自身免疫性破坏性关节炎。细胞因子是一种小而半衰期短的蛋白质,在免疫反应和炎症过程中对各种刺激的反应起关键作用。复杂的细胞和细胞因子网络参与RA的发病机制。目前研究表明肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、IL-10通过相同的信号通路丝裂原活化蛋白激酶和/或酪氨酸激酶/信号转导和转录激活因子参与RA及RA患者抑郁症的病理过程。因此,类风湿关节炎患者比一般人群有更高的抑郁患病率。通过特异性阻断这些细胞因子及相应的信号转导通路可以为RA合并抑郁症提供新的治疗靶点。

Rheumatoid arthritis(RA)is autoimmune destructive arthritis characterized by excessive secretion of certain pro-inflammatory cytokines.Cytokines are small and short half-life proteins that play a key role in immune and inflammatory response to various stimuli.Complex cellular and cytokine networks are involved in the pathogenesis of RA.Current studies have shown that tumor necrosis factor-α,interleukin(IL)-6 and IL-10 participate in the pathophysiological process of RA and depression through the same signal transduction pathways,mitogen-activated protein kinase and/or Janus kinase/signal transducer and activator of transcription.Therefore,RA patients have a higher prevalence of depression than general population.Specific blockade of these cytokines and corresponding signaling pathways may provide a new therapeutic target for RA with depression.