血尿酸水平与帕金森病风险及临床特征关系的观察

Observation on the relationship between serum uric acid level and the risk and clinical characteristics of Parkinson's disease

目的探讨血尿酸水平与帕金森病风险及临床特征的相关性。方法回顾性分析青岛市市立医院神经内科2016年9月至2018年3月收治的170例原发性帕金森病患者(观察组)的病例资料,选择同期性别、年龄相匹配的170例健康体检者为对照组,比较两组的血尿酸水平,并分析血尿酸水平与帕金森病患者临床特征的相关性。结果观察组血尿酸水平明显低于对照组,差异有显著性(P<0.05)。观察组与对照组组内男性血尿酸水平均高于女性,差异有显著性(P<0.05)。112例Hoehn-Yahr分期早期患者血尿酸水平明显高于58例Hoehn-Yahr分期中晚期患者,差异有显著性(P=0.043)。Pearson相关分析显示,帕金森病患者血尿酸水平与其病程长短、年龄、起病年龄均无相关性(r=-0.031、-0.031、-0.138,P=0.692、0.688、0.075)。结论尿酸为帕金森病的独立保护因素。

Objective To explore the correlation between blood uric acid level and Parkinson’s disease risk and clinical characteristics.Method The case data of 170 patients with primary Parkinson’s disease(observation group) admitted to the department of neurology of Qingdao municipal hospital from September 2016 to March 2018 were retrospectively analyzed, and 170 healthy subjects with matching sex and age were selected as the control group.Blood uric acid levels were compared between the two groups,and the correlation between serum uric acid level and clinical characteristics of Parkinson’s disease was analyzed. Result The blood uric acid level in the observation group was lower than that in the control group, and the difference was signi? cant(P<0.05).There are differences between the sexes in both group(P<0.05). There was statistically signi? cant in the blood uric acid level between the early group and the middle-late group(P =0.043). There was no signi? cant correlation between serum uric acid level and duration, age and age of onset of Parkinson’s disease(r=-0.031、-0.031、-0.138,P=0.692、0.688、0.075). Conclusion Uric acid is an independent protective factor for Parkinson’s disease.