IgM型核心抗体对急性乙型肝炎及慢性活动型肝炎的诊断价值

EVALUATION OF DIAGNOSTIC SIGNIFICANCE OF IGMCLASS RESPONSE E TO HEPATITIS B CORE ANTIGEN IN ACUTE AND CHRONIC ACTIVE HEPATITIS

以酶联免疫吸附试验(ELISA)检测153例各型肝炎及HBsAg携带者,试图观察(1) IgM型抗-HBc能否做为急性乙肝的血清早期诊断标志;(2) IgM型抗-HBc能否做为慢活肝血清诊断标志。检测结果:IgM抗-HBc是HBV近期感染并持续增殖的血清标志之一。

IgM anti-HBc were detected by ELISA in 153 patients with hepatitis B. The results showed:(1) IgManti-HBc were Positive in 90%(27/30) of patients with acute hepatitis B, in 70.2% (21/29) of patients with C. A. H; in 20% (4/20) of patients with C. P. H and in 5.27% (3/57) of asymptomatic HBsAg positive carriers. (2). IgM anti-HBc were detected in 26.6%(8/30) of patients with acute hepatitis B absence of HBsAg. These results seem to indicate that IgM anti-HBc is a mrker of recent HBV infection.