纳米药物在肿瘤免疫治疗中的应用

Application of Nanomedicine in Tumor Immunotherapy

肿瘤免疫治疗虽然取得了突破性进展,但因实体瘤特殊的肿瘤异质性和免疫抑制性微环境等问题,仍面临诸多挑战,如药物瘤内富集不足,反应率相对较低等。纳米药物可提高宿主免疫刺激信号和肿瘤免疫治疗效果,有望克服传统免疫治疗存在的问题。笔者首先回顾分析了纳米药物在增强天然抗肿瘤免疫和克服肿瘤抑制性微环境这两大方向的应用现状,并进一步讨论其研究热点和未来发展趋势。

Despite the breakthrough in tumor immunotherapy,immunotherapy still faces many challenges due to the special tumor heterogeneity and immunosuppressive microenvironment of solid tumors,such as low drug concentration and response rate within the tumor.The advantages of nanomedicine are supposed to overcome the problems in traditional immunotherapy and improve the host immune stimulation signals as well as tumor immunotherapy effect.This paper firstly reviews the application status of nanomedicine in enhancing natural anti-tumor immunity and overcoming tumor inhibitory microenvironment.Their research hotspots and future development trend are further disscussed.