瑞戈非尼致不良反应的文献回顾性分析

Literature review analysis of adverse drug reactions induced by regorafenib

目的:通过探讨瑞戈非尼不良反应发生的现状、规律、临床表现及转归,为临床医师安全用药提供参考依据。方法:检索2013-2018年国际学术期刊有关瑞戈非尼不良反应的个案报道,采用回顾性研究方法,对患者基本情况、疾病信息、不良反应临床表现及转归等多方面进行统计分析。结果:共纳入文献37篇,涉及不良反应共43例,其中新的不良反应12例;患者中男性24例(55.81%),女性19例(44.19%),男女比例为1∶0.79,发生的平均年龄为(61.07±10.04)岁;瑞戈非尼引起的ADRs主要发生在1个月之内(75%);其所致ADRs以消化系统(33.77%)为主,皮肤及附件损害的ADRs其次(25.97%)。结论:瑞戈非尼引起的不良反应可累及全身多个系统,临床医师和药师应了解瑞戈非尼致ADRs的规律和特点,加强用药监测,以减少不良反应的发生。

OBJECTIVE To explore the current situation,pattern,clinical manifestation and prognosis of adverse reactions of regorafenib,in order to provide a reference for clinicians to use drugs safely.METHODS Case reports of regorafenib ADRs which were published in international medical academic journals during 2013-2018 were retrieved.The retrospective study method was used to statistically analyze the basic situation,disease information,clinical manifestations and outcome of adverse reactions.RESULTS A total of 37 literatures were included,involving 43 cases,among which there were 12 cases of new ADR.24 cases(55.81%)were males and 19 cases(44.19%)were females,with a male to female ratio of 1:0.79 and a mean age of(61.07±10.04)years;.Most adverse reactions occured with in one month(n=30,75%)after therapy.Lesions of digestive system was the most commonly reported ADRs(33.77%),followed by the lesions of skin and its appendants(25.97%).CONCLUSION The adverse reactions induced by regorafenib may involve multiple systems.Clinicians and pharmacists should be aware of the regularity and characteristics of regorafenib-induced ADRs,and strengthen drug monitoring to reduce adverse reactions.