多功能介孔二氧化硅纳米粒在肿瘤治疗中的研究进展

Recent advances in multifunctional mesoporous silica nanoparticles for tumor therapy

介孔二氧化硅纳米粒由于较高的物理化学稳定性、易于官能化、低毒性以及对许多不同类型治疗剂的巨大负载能力,涉及了化学药物治疗、光热治疗、光动力治疗以及联合治疗,在肿瘤治疗方面受到极大的关注和广泛的研究探索。本文介绍了近年来基于介孔二氧化硅纳米粒作为载体在肿瘤治疗方面的一些研究报道,这些智能化的多功能性已经促使介孔二氧化硅纳米粒成为将来用于临床的非常有前途的药物纳米载体。

Given the high physicochemical stability,ease of functionalization,low toxicity,and high loading capacity for various therapeutic agents,mesoporous silica nanoparticles have made huge contribution in chemotherapy,photothermal therapy,photodynamic therapy,and synergistic therapy,which have been paid great attention and extensive research in tumor therapy.This paper overviews recent research reports in tumor therapy based on mesoporous silica nanoparticles carriers.These intelligent multifunctionalities have made mesoporous silica nanoparticles a very promising drug nanocarrier for clinical use in the future.