替加环素治疗耐碳青霉烯类肺炎克雷伯菌肺炎(CRKP)的疗效和影响因素分析

Efficacy and influencing factors of tigecycline in treatment of Carbapenem-Resistant Klebsiella Pneumonia (CRKP) infection

目的:对替加环素治疗耐碳青霉烯类肺炎克雷伯菌肺炎(CRKP)的疗效和影响因素进行分析,为临床医生用药提供参考。方法:采用回顾性研究方法,收集某院2年中使用替加环素标准剂量治疗CRKP的患者,并对其临床疗效和基本临床状况进行分析。结果:替加环素合并使用其他敏感抗生素的临床疗效优于替加环素环素单药治疗,替加环素合并使用碳青霉烯的治疗方案并不优于单药治疗,且出院死亡率较高,但差距均无显著性。患者高龄、使用呼吸机辅助通气为替加环素治疗失败的独立危险因素,适当提高患者的替加环素使用疗程以及延长在ICU病区的住院监护时间有利于替加环素疗效的发挥。结论:替加环素对于CRKP具有一定治疗价值,患者高龄以及使用呼吸机辅助通气能显著影响其临床疗效。

OBJECTIVE To analyze the efficacy and influencing factors of tigecycline in the treatment of CRKP.METHODS A retrospective study was conducted to collect patients with CRKP who were administered wtih a standard dose of tigecycline for two years.The clinical efficacy and basic clinical status were analyzed.RESULTS The clinical efficacy of tigecycline combined with other sensitive antibiotics was better than that of tigecycline monotherapy.The combination of tigecycline with carbapenem was not superior to monotherapy with a higher mortality rate at discharge,but the difference was not statistically significant.Advanced age and use of ventilator assisted ventilation were independent risk factors for tigecycline treatment failure.Proper improvement in the duration of tigecycline treatment and prolonged hospital stay in the ICU are beneficial to the efficacy of tigecycline.CONCLUSION Tigecycline is valuable in the treatment of CRKP.Advanced age and the use of ventilator-assisted ventilation can significantly affect the clinical efficacy of tigecycline.