老年人潜在不适当用药评估标准研究进展

Advances in the research on the evaluation criteria of potentially inappropriate medicine in the elderly

由于生理性衰老所致的药物代谢动力学和药物效应动力学改变等因素,老年人极易发生潜在不适当用药(PIM)的情况。目前国际上已研制出多种评价工具用于筛查老年人PIM,但各国老年人PIM标准均以所在国上市药品为基准,制定方法各异。因此,基于我国老年患者的流行病学资料,建立并优化本土化的PIM评估标准,可有效减少老年患者诊疗过程中的PIM行为。本文通过介绍国内外潜在不适当用药常用评价工具,并综述其国内应用情况及展望,以期为我国老年患者合理用药提供依据。

The elderly are highly susceptible to potentially inappropriate medicine(PIM)due to changes in pharmacokinetics and pharmacodynamics induced by physiological aging.At present,a variety of evaluation tools have been developed internationally for screening PIM in the elderly,but PIM standards for the elderly in different countries are based on the listed drugs in the host country,and the methods vary greatly.Therefore,the establishment and optimization of localized PIM evaluation criteria based on the epidemiological data of elderly patients in China can effectively reduce the PIM behaviors in the diagnosis and treatment of elderly patients.This paper introduces the common evaluation tools of potential inappropriate drug use at home and abroad and summarizes their domestic applications and prospects,so as to provide the basis for rational drug use of elderly patients in China.