耳穴金针疗法治疗气虚质慢性疲劳综合征临床研究

Clinical research of auricular gold-needle therapy in treatment of chronic fatigue syndrome of qi deficiency constitution

目的:观察耳穴金针疗法治疗气虚质慢性疲劳综合征的临床疗效并探讨其部分作用机制。方法:将120例患者随机分为耳穴金针组、耳穴贴压组和补中益气丸组,每组40例,另有不予任何干预措施的健康对照组40例。耳穴金针组予一侧耳穴金针针刺,另一侧用王不留行籽贴压,耳穴贴压组予单侧耳穴王不留行籽贴压,两组均穴取肾、心、肺、皮质下等,双耳交替,每周治疗1次,4次为一疗程,连续治疗3个疗程;补中益气丸组予口服补中益气丸6 g,每天2次,1个月为一疗程,连续服用3个疗程。观察3组患者治疗前后临床症状积分,血清免疫球蛋白IgA、IgG、IgM含量的变化,并评价3组疗效。结果:耳穴金针组总有效率为90.0%(36/40),优于耳穴贴压组的80.0%(32/40)和补中益气丸组的82.5%(33/40,均P<0.05);3组患者治疗前临床症状积分均明显高于健康对照组(均P<0.001),治疗后均比治疗前降低(均P<0.001),且耳穴金针组优于耳穴贴压组与补中益气丸组(均P<0.01);治疗前3组患者血清免疫球蛋白IgA、IgG、IgM含量均较健康对照组低(均P<0.001),3组患者治疗后均有所提高(均P<0.01),且耳穴金针组优于耳穴贴压组、补中益气丸组(均P<0.05)。结论:耳穴金针疗法治疗气虚质慢性疲劳综合征疗效显著,其作用机制可能与调节免疫功能有关。

Objective To observe the clinical therapeutic effects of auricular gold-needle therapy on chronic fatigue syndrome of qi deficiency constitution and explore its potential mechanism.Methods A total of 120 patients were randomized into an auricular gold-needle therapy group,an auricular point pressure therapy group and a Chinese herb group,40 cases in each one.Additionally,a health control group(40 cases)was set up,without any intervention.In the auricular gold-needle therapy group,the gold needle was used to stimulate the auricular points on one side and the cowherb seed pressure therapy on the other side.In the auricular point pressure therapy group,the cowherb seed pressure therapy was adopted only on one side.The auricular points were shen(CO10),xin(CO15),fei(CO14),pizhixia(AT4),etc.in the two groups.The auricular points on both sides were used alternatively.The treatment was given once a week,4 treatments as one course and the consecutive 3 courses of treatment were required.In the Chinese herb group,buzhong yiqi wan was prescribed for oral administration,6 g,twice a day,the medication for 1 month was as one session and the consecutive 3 sessions of medication were required.Before and after treatment,separately,the clinical symptom score,the levels of the serum immunoglobulins,i.e.IgA,IgG and IgM were observed in the patients of the three groups.The therapeutic effects were evaluated in the three groups.Results The total effective rate was 90.0%(36/40)in the auricular gold-needle therapy group,better than 80.0%(32/40)in the auricular point pressure therapy group and 82.5%(33/40)in the Chinese herb group(both P<0.05).Before treatment,the clinical symptom scores of the patients in the three groups were obviously higher than the health control group(all P<0.001).After treatment,the symptom scores were all reduced as compared the scores before treatment in the three groups(all P<0.001)and the symptom scores in the auricular gold-needle therapy group were better than the auricular point pressure therapy group and the Chinese herbgroup(both P<0.01).Before treatment,the levels of serum IgA,IgG and IgM of the patients in the three groups were lower than the health control group(all P<0.001).The levels were all improved after treatment in the three groups(all P<0.01),and the levels in the auricular gold-needle therapy group was better than the auricular point pressure therapy group and the Chinese herb group(all P<0.05).Conclusion The auricular gold-needle therapy achieves the significant therapeutic effects on chronic fatigue syndrome of qi deficiency constitution and its mechanism is probably related to the regulation of immune function.