壮骨片治疗肝肾亏虚型膝关节骨性关节炎的临床研究

The Clinical Study on the Effects of Zhuanggu Tablets on the Treatment of Liver Kidney Deficiency Syndrome of Knee Osteoarthritis

目的:观察壮骨片治疗膝关节骨性关节炎的有效性和安全性。方法:选取膝关节骨性关节炎患者60例,采用随机数字表法随机分为2组,壮骨片组和双氯芬酸钠组各30例。壮骨片组每日给药2次,每次4片;双氯芬酸钠组每日给药2次,每次50 mg.治疗4周后,采用WOMAC评分评定患者的临床疗效,并测定血清及关节液的炎性水平。结果:壮骨片和双氯芬酸钠治疗KOA效果明显。治疗前两组患者血清炎性因子指标和关节滑膜液炎性细胞数差异无统计学意义(P>0.05)。治疗后壮骨片组血清中炎性因子的IL-1,IL-6和TNF-α水平较双氯芬酸钠组略低,但差异无统计学意义(P>0.05)。治疗后壮骨片组与双氯芬酸钠组相比,关节液中中性粒细胞计数稍减少,但差异无统计学意义(P>0.05)。结论:口服壮骨片可有效治疗肝肾亏虚型膝关节骨性关节炎,明显降低炎症因子表达。

Objective:The aim of this study is to investigate the effect of Zhuanggu tablets on inflammatory response of liver kidney deficiency syndrome of knee osteoarthritis.Methods:Patients who were diagnosed with liver kidney deficiency syndrome of knee osteoarthritis in Shenyang orthooedic hospital were selected and divided into two groups by random number table,Zhuanggu group accepted oral Zhuanggu tablet four tablets per time(twice one day for 4 weeks),diclofenac sodium group accepted oral 50 mg diclofenac sodium(twice one day for 4 weeks).Clinical efficacy was evaluated by WOMAC score,serum inflammatory cytokines and the number of inflammatory cells in synovial fluid were recorded for all groups.Results:There was no statistically significant difference of serum inflammatory cytokines and the number inflammatory cells in synovial fluid among the three groups before treatment.After treatment,The index of serum inflammatory factors(IL-1,IL-6 and TNF-α)in Zhuanggu group was a little lower than in diclofenac sodium group and the difference was not statistically significant(P>0.05).The number of neutrophil in Zhuanggu group was also a little lower than that in diclofenac sodium group,without statistically significant differences(P>0.05).Conclusion:Oral Zhuanggu tablets can suppress the local inflammatory response in patients with liver kidney deficiency syndrome knee osteoarthritis.