替吉奥同步放疗序贯化疗治疗胃癌根治术后腹腔淋巴结转移瘤的疗效与安全性

Efficacy and safety of concurrent or sequential chemoradiotherapy with tegafur for abdominal lymph node metastasis after gastrectomy

目的探讨替吉奥同步放疗序贯化疗治疗胃癌根治术后腹腔淋巴结转移瘤的疗效与安全性。方法选取2016年1月至2018年12月间陕西省宝鸡市中心医院收治的64例胃癌根治术后腹腔淋巴结转移瘤患者,采用随机数表法将其分为观察组和对照组,每组32例,观察组患者采用替吉奥同步放疗序贯化疗,对照组患者采用放疗治疗,比较两组患者的临床疗效与不良反应情况。结果观察组患者的有效率与控制率均高于对照组患者,观察组患者的不良反应发生率低于对照组患者,差异均有统计学意义(均P <0. 05)。结论替吉奥同步放疗序贯化疗治疗胃癌根治术后腹腔淋巴结转移瘤的疗效与安全性均较佳,值得临床推行。

Objective To analyze the efficacy and safety of concurrent or sequential chemoradiotherapy with tegafur for abdominal lymph node metastasis after gastrectomy.Methods Sixty-four patients with abdominal lymph node metastases after gastrectomy treated at Baoji Central Hospital were selected from January 2016 to December 2018.They were divided into an observation group and a control group with 32 paitents in each group according to random number table method.The observation group was given concurrent or sequential chemoradiotherapy with tegafur and the control group was given radiotherapy.The clinical efficacy and adverse reactions of the two groups were compared.Results The effective rate and control rate were higher in the observation group than in the control group(P<0.05).The incidence of adverse reactions was lower in the observation group than in the control group(P<0.05).Conclusion Efficacy and safety of concurrent or sequential chemoradiotherapy with tegafur is good for abdominal lymph node metastasis after gastrectomy,which is worthy of clinical application.