乳腺癌患者SCL-90评分及与癌因性疲乏的相关性研究

SCL-90 score in patients with breast cancer and its correlation with cancer-related fatigue

目的探讨乳腺癌患者症状自评量表(SCL-90)评分与癌因性疲乏的相关性。方法选取2015年6月至2018年12月间黄州区人民医院收治的109例乳腺癌患者,发放SCL-90和癌因性疲乏量表(CFS)进行调查,采用Pearson对SCL-90和CFS的相关性进行分析。结果化疗后,患者SCL-90中除精神病性外,抑郁、焦虑、敌对、恐怖、偏执、躯体化、强迫症状、人际敏感得分及总分均高于化疗前,差异均有统计学意义(均P <0. 01)。化疗后,患者躯体疲乏、情感疲乏、认知疲乏得分及疲乏总分分别为(17. 28±3. 62)分、(9. 53±1. 01)分、(8. 00±1. 13)分和(34. 90±4. 36)分。Pearson相关性分析发现,SCL-90中抑郁、焦虑、恐怖、人际敏感及总分均与CFS总分呈正相关(均P <0. 01),其他因子与CFS总分之间未见显著相关性。结论乳腺癌患者化疗后心理问题不同程度加重,普遍存在癌因性疲乏,其严重程度与心理问题呈正相关。

Objective To investigate the score of symptom checklist(SCL-90)in patients with breast cancer and analyze its correlation with cancer-related fatigue.Methods A total of 109 patients with breast cancer admitted to Huangzhou District People’s Hospital of Huanggang from June 2015 to December2018 were selected in the study.The SCL-90 scale and cancer-related fatigue scale(CFS)were used for the survey,and Pearson was used to analyze the correlation between SCL-90 and CFS.Results After chemotherapy,the scores of all the factors other than psychosis(depression,anxiety,hostility,terror,paranoia,somatization,obsessive-compulsiveness,interpersonal sensitivity)and the total score of SCL-90 were higher than those before chemotherapy(all P<0.05).After chemotherapy,the overall score of physical fatigue,emotional fatigue,cognitive fatigue and the overall score of fatigue was 17.28±3.62,9.53±1.01,8.00±1.13 and 34.90±4.36,respectively.Pearson correlation showed that the scores of SCL-90 for depression,anxiety,terror and interpersonal sensitivity and the overall score of SCL-90 were positively correlated with the overall score of CFS(all P<0.05).For other factors,no correlation was found with the overall score of CFS.Conclusion The psychological problems are aggravated in patients with breast cancer after chemotherapy.Cancer-related fatigue is commonly widespread,and its severity is positively correlated with psychological problems.