联合检测血清肿瘤标志物对胰腺癌的诊断价值

Diagnostic value of combined detection of serum tumor markers for pancreatic cancer

目的探讨血清肿瘤标志物联合检测对胰腺癌的诊断价值。方法选取2016年7月至2019年4月间山东省职业卫生与职业病防治研究院收治的52例胰腺癌患者为胰腺癌组,58例胰腺良性患者为良性组,60例同期体检健康者为健康对照组。比较三组受试者血清糖链抗原19-9(CA19-9)、糖链抗原242(CA242)、胸苷激酶1(TK1)、肿瘤特异生长因子(TSGF)及不同临床分期的水平;评估CA19-9、CA242、TK1及TSGF联合检测对胰腺癌患者的临床诊断价值。结果三组受试者血清CA19-9、CA242、TK1及TSGF水平比较差异显著,且胰腺癌组上述指标高于其他两组,良性组上述指标高于健康对照组,差异均有统计学意义(均P <0. 05)。四期胰腺癌患者CA19-9、CA242、TK1及TSGF水平比较差异显著,且随着期数上升,CA19-9和CA242逐渐升高,Ⅲ~Ⅳ期胰腺癌患者TK1及TSGF均高于Ⅰ~Ⅱ期,差异均有统计学意义(均P <0. 05)。将CA19-9、CA242、TK1及TSGF四项纳入Logistic回归模型,四项联合敏感度和特异度为88. 5%和94. 8%,均高于单项检测。结论血清CA19-9、CA242、TK1及TSGF水平与胰腺癌关系显著,且联合检测敏感度和特异度较高,对胰腺癌的诊断和治疗具有重要价值。

Objective To investigate the diagnostic value of serum carbohydrate antigen 19-9(CA19-9),carbohydrate antigen 242(CA242),cytoplasmic thymidine kinase 1(TK1)and tumor-specific growth factor(TSGF)for pancreatic cancer.Methods Fifty-two pancreatic cancer patients diagnosed and treated at Shandong Academy of Occupational Health and Occupational Medicine from July 2016 to April2019 were selected as the pancreatic cancer group,58 patients with benign pancreas were selected as the benign group,and 60 healthy patients were selected as the healthy control group.The diagnostic value of serum levels of CA19-9,CA242,TK1,and TSGF for pancreatic cancer was evaluated.Results There were significant differences in serum CA19-9,CA242,TK1 and TSGF levels among the three groups(all P<0.05),and the above levels were higher in the pancreatic cancer group than in the rest two groups and higher in the benign group than in the healthy control group(all P<0.05).CA19-9,CA242,TK1 and TSGF levels were significant different in patients with different cancer stage(all P<0.05),and CA19-9 and CA242 levels increased with the raising stage of cancer.TK1 and TSGF levels were higher in patients with stageⅢ~Ⅳcancer than in patients with stageⅠ~Ⅳcancer(all P<0.05).CA19-9,CA242,TK1 and TSGF were included in the Logistic regression model.The sensitivity and specificity was 88.5%and94.8%,respectively,which were higher than the single detection.Conclusion Serum levels of CA19-9,CA242,TK1 and TSGF are significantly correlated with pancreatic cancer,and the sensitivity and specificity of combined detection are high,which has important value in the diagnosis and treatment of pancreatic cancer.