沙参麦冬颗粒治疗晚期肺癌患者的疗效观察

Efficacy of shashen maidong keli in the treatment of advanced lung cancer

目的探讨沙参麦冬颗粒治疗晚期非小细胞肺癌患者的临床疗效。方法选取2018年1月至2018年12月间泰兴市中医院收治的110例非小细胞肺癌患者,采用随机数表法分为联合组和对照组,每组55例。对照组患者采用化疗治疗,联合组患者采用化疗联合沙参麦冬颗粒治疗,比较两组患者的中医症候、肿瘤病灶及治疗前后癌胚抗原变化。结果治疗后,两组患者中医症候各评分均较治疗前改善,且联合组患者较对照组改善效果更好,差异均有统计学意义(均P <0. 05)。联合组患者治疗总有效率为43. 6%,高于对照组的25. 5%,两组比较,差异有统计学意义(P <0. 05)。治疗后,两组患者癌胚抗原数值较治疗前均降低,且联合组患者要更低于对照组,差异均有统计学意义(均P <0. 05)。结论沙参麦冬颗粒治疗晚期非小细胞肺癌患者,可明显改善中医症候,降低癌胚抗原水平,维持病灶稳定。

Objective To explore the clinical efficacy of shashen maidong keli in the treatment of advanced non-small cell carcinoma.Methods A total of 110 patients with non-small cell carcinoma admitted to Taixing Hospital of Traditional Chinese Medicine from January 2018 to December 2018 were selected.They were divided into two groups according to random odd-even number method with 55 patients in each group.The combination group were treated with chemotherapy combined with shashen maidong keli and the control group were treated with chemotherapy The changes in TCM symptoms,tumor lesions and carcinoembryonic antigen(CEA)were compared between the two groups before and after the treatment.Results After the treatment,the scores of main TCM symptoms were improved in both groups.Compared with the control group,the improvement of TCM symptoms was greater in the combination group than in the control group(all P<0.05).The overall efficacy rate was 43.6%in the combination group which was higher than 25.5%of the control group(P<0.05).The CEA level decreased after the treatment compared with before the treatment and the CEA level was lower in the combination group than in the control group(P<0.05).Conclusion Shashen maidong keli has obvious advantages in improving TCM symptoms of advanced lung cancer,reduce the level of CEA and ensure the stability of the lesion.