乳腺癌保乳术后大分割放疗的临床研究进展

Progress of hypofractionated radiotherapy after breast-conserving surgery

乳腺癌保乳术后行全乳腺放疗在降低局部肿瘤复发同时也可改善患者生存情况。虽然全乳腺标准放疗可以实现良好的肿瘤控制及美容效果,且具有不良反应轻的特点,但5～7周的治疗时间对患者相对较长,甚至可能造成医疗资源浪费,因此临床上越来越倾向大分割放疗和加速部分乳腺照射的短疗程放疗。短疗程放疗与常规分割放疗均为安全有效的治疗模式,具有与常规放疗相似的生存和局部肿瘤控制效果,不良反应可以耐受。相较于常规分割放疗,短疗程放疗具有缩短治疗总时间,减少治疗费用,节约医疗资源,改善患者生存质量的显著优势。

Breast-conserving surgery plus adjuvant whole-breast irradiationmay reduce the risk of local tumors and improve living conditions of patients.Conventional whole-breast radiotherapy confers good tumor control and esthetic effects with lower toxicity.However,treatment periods of 5-7 weeks are inconvenient for patients and may lead to the wastage of medical resources.Thus,increasingly more individuals tend to choose a short-term radiotherapy mode,such as hypofractionated radiotherapy or partial breast irradiation.Many published reports suggest that short-term radiotherapy is safe and effective,similar to conventional fractionation,with comparable tumor control and fewer side effects than noted with conventional fractionation.Therefore,in contrast to conventional whole-breast radiotherapy,short-time radiotherapy shows remarkable advantages in shortening the total treatment duration,reducing medical costs,saving medical resources,and improving the quality of life of patients.